Seroatlas · Human Serome Atlas

RAB24

Ras-related protein Rab-24

Also known as: RAB24_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q969Q5
Gene: RAB24
Ensembl: ENSG00000169228
Chromosome: 5
Canonical length: 203 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

RAB24 is a small GTPase of the Rab subfamily of Ras-related proteins that regulate intracellular protein trafficking (Olkkonen et al., 1993 [PubMed 8126105]).[supplied by OMIM, Aug 2009]

Canonical amino-acid sequenceUniProt

203 residues, UniProt reviewed canonical sequence.

>Q969Q5|RAB24
     1  MSGQRVDVKV VMLGKEYVGK TSLVERYVHD RFLVGPYQNT IGAAFVAKVM SVGDRTVTLG
    61  IWDTAGSERY EAMSRIYYRG AKAAIVCYDL TDSSSFERAK FWVKELRSLE EGCQIYLCGT
   121  KSDLLEEDRR RRRVDFHDVQ DYADNIKAQL FETSSKTGQS VDELFQKVAE DYVSVAAFQV
   181  MTEDKGVDLG QKPNPYFYSC CHH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB24 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 49 nTPM

Expression across tissuesHPA

Tissue

pancreas: 49 nTPM
spleen: 42 nTPM
choroid plexus: 42 nTPM
pituitary gland: 38 nTPM
cerebral cortex: 36 nTPM
skin: 35 nTPM

Single-cell type

syncytiotrophoblasts: 41 nCPM
brain excitatory neurons: 36 nCPM
other brain neurons: 34 nCPM
brain inhibitory neurons: 33 nCPM
astrocytes: 32 nCPM
epididymal principal cells: 30 nCPM

Immune cell

intermediate monocyte: 185 nTPM
non-classical monocyte: 184 nTPM
eosinophil: 167 nTPM
neutrophil: 138 nTPM
classical monocyte: 87 nTPM
myeloid DC: 60 nTPM

Brain region

choroid plexus: 29 nTPM
hypothalamus: 29 nTPM
cerebral cortex: 25 nTPM
basal ganglia: 24 nTPM
pons: 24 nTPM
white matter: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.63
gnomAD pLI: 0.15
gnomAD missense Z: 1.71
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB24 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ZFYVE20
RBSN
GDI1
GDI2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB24 as an antibody target. Whether an autoantibody or antibody against RAB24 could matter depends on whether native RAB24 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB24 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RAB24 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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