Seroatlas · Human Serome Atlas

SRPRB

Signal recognition particle receptor subunit beta

Also known as: APMCF1, SR-beta, SRPRB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y5M8
Gene
SRPRB
Ensembl
ENSG00000144867
Chromosome
3
Canonical length
271 aa
Protein class
Predicted membrane proteins
Subcellular location
Plasma membrane

OverviewNCBI Gene

The protein encoded by this gene has similarity to mouse protein which is a subunit of the signal recognition particle receptor (SR). This subunit is a transmembrane GTPase belonging to the GTPase superfamily. It anchors alpha subunit, a peripheral membrane GTPase, to the ER membrane. SR is required for the cotranslational targeting of both secretory and membrane proteins to the ER membrane. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

271 residues, UniProt reviewed canonical sequence.

>Q9Y5M8|SRPRB
     1  MASADSRRVA DGGGAGGTFQ PYLDTLRQEL QQTDPTLLSV VVAVLAVLLT LVFWKLIRSR
    61  RSSQRAVLLV GLCDSGKTLL FVRLLTGLYR DTQTSITDSC AVYRVNNNRG NSLTLIDLPG
   121  HESLRLQFLE RFKSSARAIV FVVDSAAFQR EVKDVAEFLY QVLIDSMGLK NTPSFLIACN
   181  KQDIAMAKSA KLIQQQLEKE LNTLRVTRSA APSTLDSSST APAQLGKKGK EFEFSQLPLK
   241  VEFLECSAKG GRGDVGSADI QDLEKWLAKI A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SRPRB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
89 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 89 nTPM
  • liver: 56 nTPM
  • salivary gland: 47 nTPM
  • epididymis: 45 nTPM
  • choroid plexus: 43 nTPM
  • esophagus: 33 nTPM

Single-cell type

  • plasma cells: 206 nCPM
  • esophageal suprabasal cells: 150 nCPM
  • oocytes: 143 nCPM
  • pancreatic acinar cells: 129 nCPM
  • breast lactating cells: 124 nCPM
  • gastric progenitor cells: 115 nCPM

Immune cell

  • MAIT T-cell: 73 nTPM
  • gdT-cell: 54 nTPM
  • plasmacytoid DC: 54 nTPM
  • naive CD8 T-cell: 52 nTPM
  • total PBMC: 50 nTPM
  • memory CD8 T-cell: 48 nTPM

Brain region

  • white matter: 35 nTPM
  • choroid plexus: 32 nTPM
  • midbrain: 27 nTPM
  • medulla oblongata: 27 nTPM
  • pons: 27 nTPM
  • cerebral cortex: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.83
gnomAD pLI
0.01
gnomAD missense Z
-0.01
DepMap mean gene effect
-0.66
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SRPRB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SRPRB as an antibody target. Whether an autoantibody or antibody against SRPRB could matter depends on whether native SRPRB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SRPRB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SRPRB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SRPRB. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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