RASL10B
Ras-like protein family member 10B
Also known as: RRP17, RSLAB_HUMAN, VTS58635
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96S79
- Gene
- RASL10B
- Ensembl
- ENSG00000270885
- Chromosome
- 17
- Canonical length
- 203 aa
- Protein class
- Enzymes, Predicted intracellular proteins
- Subcellular location
- Vesicles
OverviewNCBI Gene
Predicted to enable G protein activity and GTP binding activity. Predicted to be involved in positive regulation of peptide hormone secretion and regulation of systemic arterial blood pressure by atrial natriuretic peptide. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
203 residues, UniProt reviewed canonical sequence.
>Q96S79|RASL10B
1 MVSTYRVAVL GARGVGKSAI VRQFLYNEFS EVCVPTTARR LYLPAVVMNG HVHDLQILDF
61 PPISAFPVNT LQEWADTCCR GLRSVHAYIL VYDICCFDSF EYVKTIRQQI LETRVIGTSE
121 TPIIIVGNKR DLQRGRVIPR WNVSHLVRKT WKCGYVECSA KYNWHILLLF SELLKSVGCA
181 RCKHVHAALR FQGALRRNRC AIMLocalizationUniProt · AlphaFold · HPA
Whether an antibody against RASL10B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.3
- Highest tissue expression
- 33 nTPM
Expression across tissuesHPA
Tissue
- basal ganglia: 33 nTPM
- amygdala: 31 nTPM
- skeletal muscle: 30 nTPM
- cerebral cortex: 28 nTPM
- hippocampal formation: 25 nTPM
- heart muscle: 18 nTPM
Single-cell type
- late spermatids: 57 nCPM
- breast lactating cells: 24 nCPM
- müller glia: 21 nCPM
- retinal amacrine cells: 15 nCPM
- retinal pigment epithelial cells: 13 nCPM
- late primary spermatocytes: 12 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- basal ganglia: 67 nTPM
- hippocampal formation: 55 nTPM
- amygdala: 54 nTPM
- cerebral cortex: 53 nTPM
- midbrain: 41 nTPM
- hypothalamus: 38 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.13
- gnomAD pLI
- 0
- gnomAD missense Z
- 1.61
- DepMap mean gene effect
- -0.09
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- positive regulation of peptide hormone secretion
- regulation of systemic arterial blood pressure by atrial natriuretic peptide
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of RASL10B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RASL10B as an antibody target. Whether an autoantibody or antibody against RASL10B could matter depends on whether native RASL10B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RASL10B is annotated at the cell surface, where native RASL10B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label RASL10B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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