Seroatlas · Human Serome Atlas

RAB11B

Ras-related protein Rab-11B

Also known as: H-YPT3, RB11B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15907
Gene
RAB11B
Ensembl
ENSG00000185236
Chromosome
19
Canonical length
218 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins
Subcellular location
Vesicles,Primary cilium,Centriolar satellite,Basal body,Cytosol

OverviewNCBI Gene

The Ras superfamily of small GTP-binding proteins, which includes the Ras (see MIM 190020), Ral (see MIM 179550), Rho (see MIM 165390), Rap (see MIM 179520), and Rab (see MIM 179508) families, is involved in controlling a diverse set of essential cellular functions. The Rab family, including RAB11B, appears to play a critical role in regulating exocytotic and endocytotic pathways (summary by Zhu et al., 1994 [PubMed 7811277]).[supplied by OMIM, Nov 2010]

Canonical amino-acid sequenceUniProt

218 residues, UniProt reviewed canonical sequence.

>Q15907|RAB11B
     1  MGTRDDEYDY LFKVVLIGDS GVGKSNLLSR FTRNEFNLES KSTIGVEFAT RSIQVDGKTI
    61  KAQIWDTAGQ ERYRAITSAY YRGAVGALLV YDIAKHLTYE NVERWLKELR DHADSNIVIM
   121  LVGNKSDLRH LRAVPTDEAR AFAEKNNLSF IETSALDSTN VEEAFKNILT EIYRIVSQKQ
   181  IADRAAHDES PGNNVVDISV PPTTDGQKPN KLQCCQNL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB11B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
218 nTPM

Expression across tissuesHPA

Tissue

  • thyroid gland: 218 nTPM
  • spinal cord: 178 nTPM
  • heart muscle: 174 nTPM
  • blood vessel: 162 nTPM
  • midbrain: 154 nTPM
  • cerebral cortex: 149 nTPM

Single-cell type

  • esophageal apical cells: 249 nCPM
  • syncytiotrophoblasts: 244 nCPM
  • extravillous trophoblasts: 212 nCPM
  • migrating cytotrophoblasts: 183 nCPM
  • cytotrophoblasts: 168 nCPM
  • epididymal principal cells: 163 nCPM

Immune cell

  • eosinophil: 101 nTPM
  • neutrophil: 66 nTPM
  • plasmacytoid DC: 59 nTPM
  • non-classical monocyte: 56 nTPM
  • NK-cell: 54 nTPM
  • basophil: 48 nTPM

Brain region

  • medulla oblongata: 269 nTPM
  • pons: 265 nTPM
  • white matter: 248 nTPM
  • midbrain: 247 nTPM
  • thalamus: 244 nTPM
  • cerebellum: 242 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RAB11B.

Disease | AllUniProt

Conditions RAB11B is implicated in, by any mechanism.

  • Neurodevelopmental disorder with ataxic gait, absent speech, and decreased cortical white matter (NDAGSCW) MIM:617807

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 262 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.64
gnomAD pLI
0.44
gnomAD missense Z
2.48
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB11B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB11B as an antibody target. Whether an autoantibody or antibody against RAB11B could matter depends on whether native RAB11B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB11B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RAB11B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RAB11B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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