Seroatlas · Human Serome Atlas

NWD2

NACHT and WD repeat domain-containing protein 2

Also known as: KIAA1239, NWD2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9ULI1
Gene: NWD2
Ensembl: ENSG00000174145
Chromosome: 4
Canonical length: 1742 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be active in synapse. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1742 residues, UniProt reviewed canonical sequence.

>Q9ULI1|NWD2
     1  MWPAGAGTKL PCPRDSALRR AAFSGNLTAL PSHLVPAGRS VRVFISANPE DTGAERQALR
    61  ENVYPKLREF CRENYGLEFQ VIDLYWGVEE DEWDSPELQK TRMKLLENCL KTSAGPCFVG
   121  LLGEKYGNIR IPGEVEASEF EMILDAAIEA KLETKLLEEW YCRDENSVPA AYYLRPKSEM
   181  LRSNRNAMQP STNAENEKTW QEISDEIKKI FKAAVKLLHE KGKMKHSQAK RYLFSAIEDE
   241  FDFALGKQTP AFLKKCVCYI RKIANIERFV KIPEMGKYMD ITGTEPRIIR DPEAQEKLIK
   301  LRDEFIPTIV ASSNLRVYTS VTHCDMKLGY SQEIENHYIE GLGKQFYEDM IDIIQATIQQ
   361  NFDTETDTLY DEILQHSSLC KTYASFYEYK CESLNIVHNY ILPSKAGHIN PLIIYGGPCT
   421  GKTLLLAEVA KKAYGWLHED TGPESDPVVI VRFLGTTDMS SDLRTLLLSV CEQLAVNYRC
   481  LVQSYPKKIH DLCDLFINLL NESSLQRPLV IIFDALEQLS ENDDARKLWW LPAHLPRFVR
   541  IVLSTLPNKH GILQKLRCLI HEEDNYIELI PRDRKMCSQV LKHQLLRVKR KVTSGQQIYV
   601  NNALSKCTLP MFVNLTFREV RHWRSHKDVD ESSLSVTVHE SIEQLFWSLE KKCGQKLVSR
   661  ALGYITMAKM GLSEMELEDV LALDNSVMSE LKENTRPSNP LRVPYLYIAR LKEGLSGYLI
   721  ERHVKNVTLL VWANRHLQLI AQKLYLQDDN DLREMHTILA DYFLGVWSGG RRKAFCLEDP
   781  YLNGCLDLEN RSLLEEEKHF MEQASFDRQA PDQPWVFQCN PLEPDIFFVN HRKMSELLYH
   841  LTRCGKTDDL LYGIIMNFSW LYTMIKIGQF DKVLSDIELA YNYSQEKELK FLANTLRSIK
   901  NKVTAFPGSL SAELQQRLLP VVSSLPKLRH LLLECDKDGP KYCSIVPLHS SMDVTYSPER
   961  LPLSSSHLHV TEILPTCNPS TVLTALENGS ISTWDVETRQ LLRQITTAQS VILGMKLTSD
  1021  EKYLVVATTN NTLLIYDNVN SCLLSEVEIK GTKHGSSATY INGFTLSANH ALAWLEASKD
  1081  VTVIDLLYGW PLYQFHCWYE VTCVQCSLDG LYAFCGQYLN TTTIFHLGSG EKLCTVTSEF
  1141  SGGFVKFLLI LDTAQEMVMV DSEGSLSVWN TEDISSPQLT DDFDCRREDS EVVSIELSED
  1201  QSAVLICKAL SIELLDTGLW KVAEKFRAKH NERFISAVLS KNGDCIIATM ENTSAVFFWR
  1261  RDTGQCMASL QEISGSIVKL VKSSHHNMLL SLSTSGVLSI WDIDIITAMS NIDKTGKPIQ
  1321  SLLLPARGEI IYSLDGSDCV HKWNFSSGFI EAVFKHEGIV EHCVLTSTGD IMVTSDDKSS
  1381  QYVWHTSSGE NLFRINGQRI SQLLITHNDQ FVVSLCEENA SRVWRLATGH RVCNILTTLQ
  1441  NAFITSANTF VVGMTKSKVL AVSLWTGSIT KKFCCEDGTT IVNFKLIPDC PDIIVFITSA
  1501  ETVNIWSLTD EVICRRVQLP NNFLKNLEDF EISPNGKLGI IARGDENINV LDLYSGKLRV
  1561  VHASGIIWRQ RLSRDGRYLV YICFRNGEEE DENGAIFSLI VMRLADGKNI GACSLYKTPT
  1621  FLALSQRHLN IIVGFDDGSI GIYTVVDRVD AALKIKIATS NSRQIFNNAT HTSRPKCNSY
  1681  CFKISVDCLW RESTEVFARD SPITVSDSTE SNEATPSKKH NSCYERVCSA LEARGHSYAP
  1741  DN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NWD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 3.8 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 3.8 nTPM
adipose tissue: 2.3 nTPM
breast: 1.1 nTPM
hypothalamus: 1.1 nTPM
thyroid gland: 0.8 nTPM
hippocampal formation: 0.7 nTPM

Single-cell type

adipocytes: 180 nCPM
other brain neurons: 132 nCPM
brain excitatory neurons: 92 nCPM
lactotrophs: 86 nCPM
thyrotrophs: 59 nCPM
retinal amacrine cells: 41 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 18 nTPM
midbrain: 12 nTPM
pons: 11 nTPM
basal ganglia: 8.7 nTPM
hypothalamus: 5.8 nTPM
white matter: 5.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.3
gnomAD pLI: 0.98
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

synapse

Protein domainsUniProt · Pfam · InterPro

WD40 repeat
WD40/YVTN repeat-like-containing domain superfamily
P-loop containing nucleoside triphosphate hydrolase
WD40-repeat-containing domain superfamily
NWD1/2-like, winged helix-turn-helix domain
NWD1-like, winged helix-turn-helix domain
NACHT and WD repeat domain-containing protein
NWD2, C-terminal beta-propeller domain
NWD2 C-terminal beta-propeller

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NWD2 as an antibody target. Whether an autoantibody or antibody against NWD2 could matter depends on whether native NWD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NWD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NWD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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