KIF27

Protein identityUniProt · HPA

UniProt accession

Q86VH2

Gene

KIF27

Ensembl

ENSG00000165115

Chromosome

9

Canonical length

1401 aa

Protein class

Predicted intracellular proteins

OverviewNCBI Gene

This gene is a member of the KIF27 (kinesin 4) sub-family of the mammalian kinesin family. The gene is an ortholog of the Drosophila Cos2 gene, which plays an important role in the Hedgehog signaling pathway. The encoded protein contains an N-terminal motor domain which includes nucleotide-binding and microtubule-interacting regions, a stalk domain containing a predicted coiled coil motif and a C-terminal tail domain. Alternatively spliced transcript variants have been observed for this gene. Pseudogenes associated with this gene are located on chromosome 9. [provided by RefSeq, Dec 2012]

Canonical amino-acid sequenceUniProt

1401 residues, UniProt reviewed canonical sequence.

>Q86VH2|KIF27
     1  MEEIPVKVAV RIRPLLCKEA LHNHQVCVRV IPNSQQVIIG RDRVFTFDFV FGKNSTQDEV
    61  YNTCIKPLVL SLIEGYNATV FAYGQTGSGK TYTIGGGHIA SVVEGQKGII PRAIQEIFQS
   121  ISEHPSIDFN VKVSYIEVYK EDLRDLLELE TSMKDLHIRE DEKGNTVIVG AKECHVESAG
   181  EVMSLLEMGN AARHTGTTQM NEHSSRSHAI FTISICQVHK NMEAAEDGSW YSPRHIVSKF
   241  HFVDLAGSER VTKTGNTGER FKESIQINSG LLALGNVISA LGDPRRKSSH IPYRDAKITR
   301  LLKDSLGGSA KTVMITCVSP SSSNFDESLN SLKYANRARN IRNKPTVNFS PESDRIDEME
   361  FEIKLLREAL QSQQAGVSQT TQINREGSPD TNRIHSLEEQ VAQLQGECLG YQCCVEEAFT
   421  FLVDLKDTVR LNEKQQHKLQ EWFNMIQEVR KAVLTSFRGI GGTASLEEGP QHVTVLQLKR
   481  ELKKCQCVLA ADEVVFNQKE LEVKELKNQV QMMVQENKGH AVSLKEAQKV NRLQNEKIIE
   541  QQLLVDQLSE ELTKLNLSVT SSAKENCGDG PDARIPERRP YTVPFDTHLG HYIYIPSRQD
   601  SRKVHTSPPM YSLDRIFAGF RTRSQMLLGH IEEQDKVLHC QFSDNSDDEE SEGQEKSGTR
   661  CRSRSWIQKP DSVCSLVELS DTQDETQKSD LENEDLKIDC LQESQELNLQ KLKNSERILT
   721  EAKQKMRELT INIKMKEDLI KELIKTGNDA KSVSKQYSLK VTKLEHDAEQ AKVELIETQK
   781  QLQELENKDL SDVAMKVKLQ KEFRKKMDAA KLRVQVLQKK QQDSKKLASL SIQNEKRANE
   841  LEQSVDHMKY QKIQLQRKLR EENEKRKQLD AVIKRDQQKI KEIQLKTGQE EGLKPKAEDL
   901  DACNLKRRKG SFGSIDHLQK LDEQKKWLDE EVEKVLNQRQ ELEELEADLK KREAIVSKKE
   961  ALLQEKSHLE NKKLRSSQAL NTDSLKISTR LNLLEQELSE KNVQLQTSTA EEKTKISEQV
  1021  EVLQKEKDQL QKRRHNVDEK LKNGRVLSPE EEHVLFQLEE GIEALEAAIE YRNESIQNRQ
  1081  KSLRASFHNL SRGEANVLEK LACLSPVEIR TILFRYFNKV VNLREAERKQ QLYNEEMKMK
  1141  VLERDNMVRE LESALDHLKL QCDRRLTLQQ KEHEQKMQLL LHHFKEQDGE GIMETFKTYE
  1201  DKIQQLEKDL YFYKKTSRDH KKKLKELVGE AIRRQLAPSE YQEAGDGVLK PEGGGMLSEE
  1261  LKWASRPESM KLSGREREMD SSASSLRTQP NPQKLWEDIP ELPPIHSSLA PPSGHMLGNE
  1321  NKTETDDNQF TKSHSRLSSQ IQVVGNVGRL HGVTPVKLCR KELRQISALE LSLRRSSLGV
  1381  GIGSMAADSI EVSRKPRDLK T

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIF27 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.45

Highest tissue expression

25 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.9

gnomAD pLI

0

gnomAD missense Z

0.53

DepMap mean gene effect

-0.17

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cilium assembly
• epithelial cilium movement involved in extracellular fluid movement
• establishment of localization in cell
• microtubule-based movement
• ventricular system development

Molecular functions

• ATP binding
• ATP hydrolysis activity
• microtubule binding
• microtubule motor activity

Cellular components

• cilium
• cytoplasm
• extracellular region
• kinesin complex
• microtubule

Protein domainsUniProt · Pfam · InterPro

• Kinesin motor domain
• Kinesin motor domain, conserved site
• P-loop containing nucleoside triphosphate hydrolase
• Kinesin-like protein
• Kinesin motor domain superfamily
• Kinesin motor domain
• KIF21A-like domain

KeywordsUniProt

• ATP-binding
• Cell projection
• Cilium
• Cilium biogenesis/degradation
• Coiled coil
• Cytoplasm
• Cytoskeleton
• Microtubule
• Motor protein
• Nucleotide-binding
• Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of KIF27 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• STK36