Seroatlas · Human Serome Atlas

RASL11A

Ras-like protein family member 11A

Also known as: RSLBA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6T310
Gene: RASL11A
Ensembl: ENSG00000122035
Chromosome: 13
Canonical length: 242 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nuclear bodies

OverviewNCBI Gene

Predicted to enable G protein activity and GTP binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase I. Predicted to be located in nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

242 residues, UniProt reviewed canonical sequence.

>Q6T310|RASL11A
     1  MRPLSMSGHF LLAPIPESSS DYLLPKDIKL AVLGAGRVGK SAMIVRFLTK RFIGDYEPNT
    61  GKLYSRLVYV EGDQLSLQIQ DTPGGVQIQD SLPQVVDSLS KCVQWAEGFL LVYSITDYDS
   121  YLSIRPLYQH IRKVHPDSKA PVIIVGNKGD LLHARQVQTQ DGIQLANELG SLFLEISTSE
   181  NYEDVCDVFQ HLCKEVSKMH GLSGERRRAS IIPRPRSPNM QDLKRRFKQA LSPKVKAPSA
   241  LG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RASL11A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 17 nTPM
adipose tissue: 16 nTPM
kidney: 13 nTPM
rectum: 12 nTPM
breast: 11 nTPM
lymph node: 10 nTPM

Single-cell type

vascular smooth muscle cells: 114 nCPM
colonocytes: 108 nCPM
enterocytes: 101 nCPM
pericytes: 96 nCPM
smooth muscle cells: 62 nCPM
epicardial cells: 50 nCPM

Immune cell

non-classical monocyte: 1.3 nTPM
naive B-cell: 1.2 nTPM
intermediate monocyte: 0.5 nTPM
basophil: 0.4 nTPM
classical monocyte: 0.4 nTPM
eosinophil: 0.4 nTPM

Brain region

thalamus: 6 nTPM
basal ganglia: 5.8 nTPM
cerebral cortex: 5.6 nTPM
hippocampal formation: 5.6 nTPM
cerebellum: 5.4 nTPM
white matter: 3.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.65
gnomAD pLI: 0
gnomAD missense Z: 0.8
DepMap mean gene effect: -0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

positive regulation of transcription by RNA polymerase I

Molecular functions

Cellular components

nucleolus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RASL11A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

UBTF

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RASL11A as an antibody target. Whether an autoantibody or antibody against RASL11A could matter depends on whether native RASL11A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RASL11A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RASL11A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...