Seroatlas · Human Serome Atlas

ARL16

ADP-ribosylation factor-like protein 16

Also known as: ARL16_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q0P5N6
Gene: ARL16
Canonical length: 197 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for ARL16 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

197 residues, UniProt reviewed canonical sequence.

>Q0P5N6|ARL16
     1  MRVAGGRALS RGAELRVPGG AKHGMCLLLG ATGVGKTLLV KRLQEVSSRD GKGDLGEPPP
    61  TRPTVGTNLT DIVAQRKITI RELGGCMGPI WSSYYGNCRS LLFVMDASDP TQLSASCVQL
   121  LGLLSAEQLA EASVLILFNK IDLPCYMSTE EMKSLIRLPD IIACAKQNIT TAEISAREGT
   181  GLAGVLAWLQ ATHRAND

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARL16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 49 nTPM

Expression across tissuesHPA

Tissue

amygdala: 49 nTPM
cerebral cortex: 47 nTPM
hippocampal formation: 44 nTPM
kidney: 41 nTPM
basal ganglia: 37 nTPM
midbrain: 36 nTPM

Single-cell type

breast lactating cells: 92 nCPM
cytotrophoblasts: 73 nCPM
esophageal suprabasal cells: 71 nCPM
esophageal apical cells: 71 nCPM
differentiating spermatogonia: 69 nCPM
epididymal principal cells: 68 nCPM

Immune cell

naive B-cell: 52 nTPM
memory B-cell: 43 nTPM
NK-cell: 42 nTPM
basophil: 42 nTPM
plasmacytoid DC: 32 nTPM
naive CD4 T-cell: 32 nTPM

Brain region

hippocampal formation: 23 nTPM
basal ganglia: 21 nTPM
cerebral cortex: 21 nTPM
white matter: 20 nTPM
spinal cord: 19 nTPM
cerebellum: 18 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ARL16.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 43 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Childhood-onset schizophrenia

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.87
gnomAD pLI: 0
gnomAD missense Z: -0.72
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARL16 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

RIGI

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARL16 as an antibody target. Whether an autoantibody or antibody against ARL16 could matter depends on whether native ARL16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARL16 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARL16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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