Seroatlas · Human Serome Atlas

RAB19

Ras-related protein Rab-19

Also known as: RAB19_HUMAN, RAB19B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A4D1S5
Gene
RAB19
Ensembl
ENSG00000146955
Chromosome
7
Canonical length
217 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable GTPase activity. Predicted to be involved in autophagosome assembly and intracellular protein transport. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

217 residues, UniProt reviewed canonical sequence.

>A4D1S5|RAB19
     1  MHFSSSARAA DENFDYLFKI ILIGDSNVGK TCVVQHFKSG VYTETQQNTI GVDFTVRSLD
    61  IDGKKVKMQV WDTAGQERFR TITQSYYRSA HAAIIAYDLT RRSTFESIPH WIHEIEKYGA
   121  ANVVIMLIGN KCDLWEKRHV LFEDACTLAE KYGLLAVLET SAKESKNIEE VFVLMAKELI
   181  ARNSLHLYGE SALNGLPLDS SPVLMAQGPS EKTHCTC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
3.5 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 3.5 nTPM
  • parathyroid gland: 2.9 nTPM
  • pancreas: 2.5 nTPM
  • rectum: 2.5 nTPM
  • colon: 2.1 nTPM
  • duodenum: 2 nTPM

Single-cell type

  • neutrophil progenitors: 58 nCPM
  • neutrophils: 21 nCPM
  • foveolar cells: 13 nCPM
  • tuft cells: 12 nCPM
  • neuroendocrine cells: 9.4 nCPM
  • epididymal efferent duct ciliated cells: 8.8 nCPM

Immune cell

  • T-reg: 2 nTPM
  • MAIT T-cell: 1.6 nTPM
  • memory CD8 T-cell: 1.4 nTPM
  • naive CD8 T-cell: 1.2 nTPM
  • neutrophil: 1.2 nTPM
  • naive CD4 T-cell: 1.1 nTPM

Brain region

  • white matter: 9 nTPM
  • cerebellum: 8.6 nTPM
  • cerebral cortex: 7.8 nTPM
  • thalamus: 7.7 nTPM
  • amygdala: 7.3 nTPM
  • pons: 7.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.87
gnomAD pLI
0
gnomAD missense Z
0.38
DepMap mean gene effect
0.17
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB19 as an antibody target. Whether an autoantibody or antibody against RAB19 could matter depends on whether native RAB19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB19 is annotated at the cell surface, where native RAB19 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RAB19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RAB19. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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