MYO1H

Protein identityUniProt · HPA

UniProt accession

Q8N1T3

Gene

MYO1H

Canonical length

1032 aa

Protein class

Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for MYO1H in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

1032 residues, UniProt reviewed canonical sequence.

>Q8N1T3|MYO1H
     1  MEGALTARDK VGVQDFVLLD AYTSESAFVD NLRKRFSENL IYTYIGTLLV SVNPYQELGI
    61  YTVSQMELYQ GVNFFELPPH VYAIADNAYR MMCAELNNHF ILISGESGAG KTEASKKILE
   121  YFAVTCPMTQ SLQIARDRLL FSNPVLEAFG NARTLRNDNS SRFGKYMDIQ FDFQGIPVGG
   181  HIISYLIEKS RVVYQNEGER NFHIFYQLLA GGEEERLSYL GLERDPQLYK YLSQGHCAKE
   241  SSISDKNDWK TVSNAFSVID FTEADLENLF GIIASVLHLG NIGFEEDDQG CATIPDTHEI
   301  KWIAKLLGVH PSVLLEALTH RKIEAKTEEV ICPLTLELSV YARDAMAKAV YGRTFTWLVN
   361  KINSSLVNKV GQRILDPLLL LTWKTVIGLL DIYGFEVFDK NGFEQFCINY CNEKLQQLLI
   421  ERTLKAEQAE YEMEGIEWEP IKYFNNKIIC DLVEERHKGI ISILDEECIR PGPATDLSFL
   481  EKLEEKVGKH AHFETRKLAG PKGRKRIGWM EFRLLHYAGE VTYCTKGFLE KNNDLLYRHL
   541  KEVLCKSKNI ILRECFLLAE LENRRRPPTV GTQFKNSLSS LLETLISKEP SYIRCIKPND
   601  RKEPSKFDDF LIRHQIKYLG LMEHLRVRRA GFAYRRKYEH FLQRYKSLCP DTWPHWHGPP
   661  AEGVERLIKY IGYKPEEYKL GKTKIFIRFP RTLFATEDAF EFSKHQLVAR IQATYKRCLG
   721  RREYVKKRQA AIKLEAHWRG ALARKAIQRR KWAVRIIRKF IKGFISRNKP LCPDNEEFIV
   781  FVRKNYILNL RYHLPKTVLD KSWLRPPGIL ENASDLLRKM CVRNLVQKYC RGITAERKAM
   841  MQQKVVTSEI FRGRKDGYTE SLNQPFVNSR IDEGDINPKV LQLISHEKIQ YGVPVIKYDR
   901  KGFKARQRQL ILTQKAAYVV ELAKIKQKIE YSALKGVSTS NLSDGILVIH VSPEDSKQKG
   961  DAVLQCGHVF EAVTKLVMLV KKENIVNVVQ GSLQFFISPG KEGTIVFDTG LEEQVYKNKN
  1021  GQLTVVSVRR KS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MYO1H can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.27

Highest tissue expression

1 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MYO1H.

Disease | AllUniProt

Conditions MYO1H is implicated in, by any mechanism.

• Central hypoventilation syndrome, congenital, 2, and autonomic dysfunction (CCHS2) MIM:619482

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 218 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Central hypoventilation syndrome, congenital, 2, and autonomic dysfunction

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.96

gnomAD pLI

0

gnomAD missense Z

0.65

DepMap mean gene effect

-0.23

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• actin filament organization
• actin filament-based movement
• endocytosis

Molecular functions

• actin filament binding
• ATP binding
• microfilament motor activity

Cellular components

• actin cytoskeleton
• actin filament
• cytoplasm
• microvillus
• myosin complex
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Myosin head, motor domain-like
• Class I myosin tail homology domain
• P-loop containing nucleoside triphosphate hydrolase
• Class I myosin, motor domain
• Kinesin motor domain superfamily
• Myosin head (motor domain)
• Unconventional myosin tail, actin- and lipid-binding

KeywordsUniProt

• Actin-binding
• ATP-binding
• Motor protein
• Myosin
• Nucleotide-binding
• Phosphoprotein
• Repeat