Seroatlas · Human Serome Atlas

SBNO1

Protein strawberry notch homolog 1

Also known as: FLJ10701, FLJ10833, MOP3, SBNO1_HUMAN, Sno

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A3KN83
Gene: SBNO1
Ensembl: ENSG00000139697
Chromosome: 12
Canonical length: 1393 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable chromatin DNA binding activity and histone binding activity. Predicted to be involved in several processes, including negative regulation of neuroinflammatory response; positive regulation of neural precursor cell proliferation; and regulation of signal transduction. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1393 residues, UniProt reviewed canonical sequence.

>A3KN83|SBNO1
     1  MVEPGQDLLL AALSESGISP NDLFDIDGGD AGLATPMPTP SVQQSVPLSA LELGLETEAA
    61  VPVKQEPETV PTPALLNVRQ QPPSTTTFVL NQINHLPPLG STIVMTKTPP VTTNRQTITL
   121  TKFIQTTAST RPSVSAPTVR NAMTSAPSKD QVQLKDLLKN NSLNELMKLK PPANIAQPVA
   181  TAATDVSNGT VKKESSNKEG ARMWINDMKM RSFSPTMKVP VVKEDDEPEE EDEEEMGHAE
   241  TYAEYMPIKL KIGLRHPDAV VETSSLSSVT PPDVWYKTSI SEETIDNGWL SALQLEAITY
   301  AAQQHETFLP NGDRAGFLIG DGAGVGKGRT IAGIIYENYL LSRKRALWFS VSNDLKYDAE
   361  RDLRDIGAKN ILVHSLNKFK YGKISSKHNG SVKKGVIFAT YSSLIGESQS GGKYKTRLKQ
   421  LLHWCGDDFD GVIVFDECHK AKNLCPVGSS KPTKTGLAVL ELQNKLPKAR VVYASATGAS
   481  EPRNMAYMNR LGIWGEGTPF REFSDFIQAV ERRGVGAMEI VAMDMKLRGM YIARQLSFTG
   541  VTFKIEEVLL SQSYVKMYNK AVKLWVIARE RFQQAADLID AEQRMKKSMW GQFWSAHQRF
   601  FKYLCIASKV KRVVQLAREE IKNGKCVVIG LQSTGEARTL EALEEGGGEL NDFVSTAKGV
   661  LQSLIEKHFP APDRKKLYSL LGIDLTAPSN NSSPRDSPCK ENKIKKRKGE EITREAKKAR
   721  KVGGLTGSSS DDSGSESDAS DNEESDYESS KNMSSGDDDD FNPFLDESNE DDENDPWLIR
   781  KDHKKNKEKK KKKSIDPDSI QSALLASGLG SKRPSFSSTP VISPAPNSTP ANSNTNSNSS
   841  LITSQDAVER AQQMKKDLLD KLEKLAEDLP PNTLDELIDE LGGPENVAEM TGRKGRVVSN
   901  DDGSISYESR SELDVPVEIL NITEKQRFMD GDKNIAIISE AASSGISLQA DRRAKNQRRR
   961  VHMTLELPWS ADRAIQQFGR THRSNQVTAP EYVFLISELA GEQRFASIVA KRLESLGALT
  1021  HGDRRATESR DLSRFNFDNK YGRNALEIVM KSIVNLDSPM VSPPPDYPGE FFKDVRQGLI
  1081  GVGLINVEDR SGILTLDKDY NNIGKFLNRI LGMEVHQQNA LFQYFADTLT AVVQNAKKNG
  1141  RYDMGILDLG SGDEKVRKSD VKKFLTPGYS TSGHVELYTI SVERGMSWEE ATKIWAELTG
  1201  PDDGFYLSLQ IRNNKKTAIL VKEVNPKKKL FLVYRPNTGK QLKLEIYADL KKKYKKVVSD
  1261  DALMHWLDQY NSSADTCTHA YWRGNCKKAS LGLVCEIGLR CRTYYVLCGS VLSVWTKVEG
  1321  VLASVSGTNV KMQIVRLRTE DGQRIVGLII PANCVSPLVN LLSTSDQSQQ LAVQQKQLWQ
  1381  QHHPQSITNL SNA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SBNO1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

testis: 35 nTPM
bone marrow: 16 nTPM
cerebellum: 12 nTPM
retina: 9.5 nTPM
thyroid gland: 9.3 nTPM
skeletal muscle: 9.1 nTPM

Single-cell type

late primary spermatocytes: 368 nCPM
undifferentiated spermatogonia: 326 nCPM
neutrophils: 295 nCPM
differentiating spermatogonia: 214 nCPM
early primary spermatocytes: 207 nCPM
neutrophil progenitors: 175 nCPM

Immune cell

non-classical monocyte: 8 nTPM
MAIT T-cell: 7.5 nTPM
gdT-cell: 7.2 nTPM
naive CD4 T-cell: 6.9 nTPM
naive CD8 T-cell: 6.9 nTPM
memory CD4 T-cell: 6.6 nTPM

Brain region

cerebellum: 35 nTPM
cerebral cortex: 30 nTPM
white matter: 27 nTPM
basal ganglia: 26 nTPM
hippocampal formation: 26 nTPM
medulla oblongata: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.08
gnomAD pLI: 1
gnomAD missense Z: 3.36
DepMap mean gene effect: -1.34
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SBNO1 as an antibody target. Whether an autoantibody or antibody against SBNO1 could matter depends on whether native SBNO1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SBNO1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SBNO1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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