Seroatlas · Human Serome Atlas

ARL14

ADP-ribosylation factor-like protein 14

Also known as: ARF7, ARL14_HUMAN, FLJ22595

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N4G2
Gene: ARL14
Ensembl: ENSG00000179674
Chromosome: 3
Canonical length: 192 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable GTP binding activity. Predicted to be involved in intracellular protein transport and vesicle-mediated transport. Predicted to be located in cytoplasmic vesicle. Predicted to be active in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

192 residues, UniProt reviewed canonical sequence.

>Q8N4G2|ARL14
     1  MGSLGSKNPQ TKQAQVLLLG LDSAGKSTLL YKLKLAKDIT TIPTIGFNVE MIELERNLSL
    61  TVWDVGGQEK MRTVWGCYCE NTDGLVYVVD STDKQRLEES QRQFEHILKN EHIKNVPVVL
   121  LANKQDMPGA LTAEDITRMF KVKKLCSDRN WYVQPCCALT GEGLAQGFRK LTGFVKSHMK
   181  SRGDTLAFFK QN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARL14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 121 nTPM

Expression across tissuesHPA

Tissue

gallbladder: 121 nTPM
stomach: 73 nTPM
duodenum: 48 nTPM
colon: 40 nTPM
rectum: 34 nTPM
small intestine: 32 nTPM

Single-cell type

colonocytes: 353 nCPM
urothelial cells: 274 nCPM
foveolar cells: 262 nCPM
enterocytes: 166 nCPM
goblet cells: 147 nCPM
enteric transient amplifying cells: 84 nCPM

Immune cell

memory B-cell: 1.8 nTPM
naive B-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

amygdala: 0.1 nTPM
cerebral cortex: 0.1 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.89
gnomAD pLI: 0
gnomAD missense Z: -1.11
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARL14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ARL14EP

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARL14 as an antibody target. Whether an autoantibody or antibody against ARL14 could matter depends on whether native ARL14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARL14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARL14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...