Seroatlas · Human Serome Atlas

RAB6A

Ras-related protein Rab-6A

Also known as: RAB6, RAB6A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P20340
Gene
RAB6A
Ensembl
ENSG00000175582
Chromosome
11
Canonical length
208 aa
Protein class
Predicted intracellular proteins
Subcellular location
Golgi apparatus,Basal body

OverviewNCBI Gene

This gene encodes a member of the RAB family, which belongs to the small GTPase superfamily. GTPases of the RAB family bind to various effectors to regulate the targeting and fusion of transport carriers to acceptor compartments. This protein is located at the Golgi apparatus, which regulates trafficking in both a retrograde (from early endosomes and Golgi to the endoplasmic reticulum) and an anterograde (from the Golgi to the plasma membrane) directions. Myosin II is an effector of this protein in these processes. This protein is also involved in assembly of human cytomegalovirus (HCMV) by interacting with the cellular protein Bicaudal D1, which interacts with the HCMV virion tegument protein, pp150. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

208 residues, UniProt reviewed canonical sequence.

>P20340|RAB6A
     1  MSTGGDFGNP LRKFKLVFLG EQSVGKTSLI TRFMYDSFDN TYQATIGIDF LSKTMYLEDR
    61  TVRLQLWDTA GQERFRSLIP SYIRDSTVAV VVYDITNVNS FQQTTKWIDD VRTERGSDVI
   121  IMLVGNKTDL ADKRQVSIEE GERKAKELNV MFIETSAKAG YNVKQLFRRV AAALPGMEST
   181  QDRSREDMID IKLEKPQEQP VSEGGCSC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB6A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
148 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 148 nTPM
  • basal ganglia: 104 nTPM
  • amygdala: 103 nTPM
  • hypothalamus: 103 nTPM
  • hippocampal formation: 103 nTPM
  • skeletal muscle: 101 nTPM

Single-cell type

  • esophageal apical cells: 481 nCPM
  • syncytiotrophoblasts: 360 nCPM
  • retinal ganglion cells: 290 nCPM
  • extravillous trophoblasts: 285 nCPM
  • enterocytes: 272 nCPM
  • choroid plexus epithelial cells: 270 nCPM

Immune cell

  • basophil: 232 nTPM
  • eosinophil: 135 nTPM
  • total PBMC: 112 nTPM
  • non-classical monocyte: 90 nTPM
  • intermediate monocyte: 89 nTPM
  • T-reg: 88 nTPM

Brain region

  • pons: 227 nTPM
  • cerebral cortex: 211 nTPM
  • hypothalamus: 203 nTPM
  • medulla oblongata: 202 nTPM
  • hippocampal formation: 198 nTPM
  • thalamus: 195 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.34
gnomAD pLI
0.95
gnomAD missense Z
2.5
DepMap mean gene effect
-0.53
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB6A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB6A as an antibody target. Whether an autoantibody or antibody against RAB6A could matter depends on whether native RAB6A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB6A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RAB6A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RAB6A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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