Seroatlas · Human Serome Atlas

RRAGB

Ras-related GTP-binding protein B

Also known as: RRAGB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VZM2
Gene: RRAGB
Ensembl: ENSG00000083750
Chromosome: X
Canonical length: 374 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus,Vesicles

OverviewNCBI Gene

Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

374 residues, UniProt reviewed canonical sequence.

>Q5VZM2|RRAGB
     1  MEESDSEKTT EKENLGPRMD PPLGEPEGSL GWVLPNTAMK KKVLLMGKSG SGKTSMRSII
    61  FANYIARDTR RLGATILDRI HSLQINSSLS TYSLVDSVGN TKTFDVEHSH VRFLGNLVLN
   121  LWDCGGQDTF MENYFTSQRD NIFRNVEVLI YVFDVESREL EKDMHYYQSC LEAILQNSPD
   181  AKIFCLVHKM DLVQEDQRDL IFKEREEDLR RLSRPLECSC FRTSIWDETL YKAWSSIVYQ
   241  LIPNVQQLEM NLRNFAEIIE ADEVLLFERA TFLVISHYQC KEQRDAHRFE KISNIIKQFK
   301  LSCSKLAASF QSMEVRNSNF AAFIDIFTSN TYVMVVMSDP SIPSAATLIN IRNARKHFEK
   361  LERVDGPKQC LLMR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RRAGB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 33 nTPM

Expression across tissuesHPA

Tissue

epididymis: 33 nTPM
ovary: 22 nTPM
parathyroid gland: 22 nTPM
thyroid gland: 22 nTPM
hypothalamus: 20 nTPM
cerebral cortex: 20 nTPM

Single-cell type

sertoli cells: 105 nCPM
oocytes: 97 nCPM
adrenal cortex cells: 85 nCPM
epididymal principal cells: 75 nCPM
proximal tubule cells: 67 nCPM
renal connecting tubule cells: 65 nCPM

Immune cell

naive B-cell: 10 nTPM
T-reg: 7.6 nTPM
MAIT T-cell: 7.5 nTPM
naive CD8 T-cell: 7.5 nTPM
naive CD4 T-cell: 7.4 nTPM
myeloid DC: 7.3 nTPM

Brain region

hypothalamus: 28 nTPM
midbrain: 26 nTPM
cerebral cortex: 24 nTPM
basal ganglia: 24 nTPM
hippocampal formation: 23 nTPM
pons: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.43
gnomAD pLI: 0.84
gnomAD missense Z: 1.94
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

GTP binding
GTPase activity
GTPase binding
guanyl ribonucleotide binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RRAGB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RRAGB as an antibody target. Whether an autoantibody or antibody against RRAGB could matter depends on whether native RRAGB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RRAGB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RRAGB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...