Seroatlas · Human Serome Atlas

CENPM

Centromere protein M

Also known as: C22orf18, CENP-M, CENPM_HUMAN, MGC861, Pane1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NSP4
Gene: CENPM
Ensembl: ENSG00000100162
Chromosome: 22
Canonical length: 180 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is an inner protein of the kinetochore, the multi-protein complex that binds spindle microtubules to regulate chromosome segregation during cell division. It belongs to the constitutive centromere-associated network protein group, whose members interact with outer kinetochore proteins and help to maintain centromere identity at each cell division cycle. The protein is structurally related to GTPases but cannot bind guanosine triphosphate. A point mutation that affects interaction with another constitutive centromere-associated network protein, CENP-I, impairs kinetochore assembly and chromosome alignment, suggesting that it is required for kinetochore formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Canonical amino-acid sequenceUniProt

180 residues, UniProt reviewed canonical sequence.

>Q9NSP4|CENPM
     1  MSVLRPLDKL PGLNTATILL VGTEDALLQQ LADSMLKEDC ASELKVHLAK SLPLPSSVNR
    61  PRIDLIVFVV NLHSKYSLQN TEESLRHVDA SFFLGKVCFL ATGAGRESHC SIHRHTVVKL
   121  AHTYQSPLLY CDLEVEGFRA TMAQRLVRVL QICAGHVPGV SALNLLSLLR SSEGPSLEDL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CENPM can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 27 nTPM
lymph node: 23 nTPM
thymus: 21 nTPM
tonsil: 15 nTPM
testis: 13 nTPM
spleen: 11 nTPM

Single-cell type

epididymal efferent duct ciliated cells: 157 nCPM
endometrial ciliated cells: 119 nCPM
fallopian tube ciliated cells: 115 nCPM
respiratory ciliated cells: 87 nCPM
enteric transient amplifying cells: 87 nCPM
erythrocyte progenitors: 85 nCPM

Immune cell

T-reg: 51 nTPM
naive B-cell: 39 nTPM
memory B-cell: 28 nTPM
memory CD4 T-cell: 19 nTPM
MAIT T-cell: 8.8 nTPM
memory CD8 T-cell: 8.4 nTPM

Brain region

cerebellum: 3.8 nTPM
thalamus: 2 nTPM
medulla oblongata: 1.7 nTPM
midbrain: 1.7 nTPM
hypothalamus: 1.4 nTPM
cerebral cortex: 1.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.1
gnomAD pLI: 0.02
gnomAD missense Z: 0.54
DepMap mean gene effect: -0.99
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

chromosome segregation

Cellular components

Protein domainsUniProt · Pfam · InterPro

P-loop containing nucleoside triphosphate hydrolase
Centromere protein Cenp-M
Centromere protein M (CENP-M)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CENPM in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CENPM as an antibody target. Whether an autoantibody or antibody against CENPM could matter depends on whether native CENPM is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CENPM is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CENPM as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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