Seroatlas · Human Serome Atlas

SULT1A4

Sulfotransferase 1A4

Also known as: ST1A4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DMN0
Gene: SULT1A4
Ensembl: ENSG00000213648
Chromosome: 16
Canonical length: 295 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16, this gene and SULT1A3 arose from a segmental duplication. Read-through transcription exists between this gene and the upstream SLX1B (SLX1 structure-specific endonuclease subunit homolog B) gene that encodes a protein containing GIY-YIG domains. [provided by RefSeq, Nov 2010]

Canonical amino-acid sequenceUniProt

295 residues, UniProt reviewed canonical sequence.

>P0DMN0|SULT1A4
     1  MELIQDTSRP PLEYVKGVPL IKYFAEALGP LQSFQARPDD LLINTYPKSG TTWVSQILDM
    61  IYQGGDLEKC NRAPIYVRVP FLEVNDPGEP SGLETLKDTP PPRLIKSHLP LALLPQTLLD
   121  QKVKVVYVAR NPKDVAVSYY HFHRMEKAHP EPGTWDSFLE KFMAGEVSYG SWYQHVQEWW
   181  ELSRTHPVLY LFYEDMKENP KREIQKILEF VGRSLPEETM DFMVQHTSFK EMKKNPMTNY
   241  TTVPQELMDH SISPFMRKGM AGDWKTTFTV AQNERFDADY AEKMAGCSLS FRSEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SULT1A4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

duodenum: 27 nTPM
small intestine: 27 nTPM
colon: 8.4 nTPM
heart muscle: 7.8 nTPM
rectum: 7.1 nTPM
spleen: 7 nTPM

Single-cell type

colonocytes: 0.6 nCPM
endometrial secretory cells: 0.3 nCPM
distal convoluted tubule cells: 0.2 nCPM
enteric stem cells: 0.2 nCPM
enteric transient amplifying cells: 0.2 nCPM
goblet cells: 0.2 nCPM

Immune cell

intermediate monocyte: 25 nTPM
myeloid DC: 18 nTPM
classical monocyte: 7.2 nTPM
non-classical monocyte: 5.6 nTPM
total PBMC: 5.4 nTPM
basophil: 1.9 nTPM

Brain region

medulla oblongata: 5.8 nTPM
cerebral cortex: 5.7 nTPM
hypothalamus: 5 nTPM
pons: 4.5 nTPM
white matter: 4.4 nTPM
cerebellum: 4.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.74
gnomAD pLI: 0.38
gnomAD missense Z: 0.98

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SULT1A4 as an antibody target. Whether an autoantibody or antibody against SULT1A4 could matter depends on whether native SULT1A4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SULT1A4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SULT1A4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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