DDX12P
Putative ATP-dependent DNA helicase DDX12
Also known as: DDX12_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for DDX12P in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
950 residues, UniProt reviewed canonical sequence.
>Q92771|DDX12P
1 MRSGGGCSGS LSLRGPASFK FSGVCPDSRG LAFSVAILPA KKEDFMAELY RVLEAGKIGI
61 FESPTGTGKS LSLICGALSW LRDFEQKKRE EEARLLETGT GPLHDEKDES LCLSSSCEGA
121 AGTPRPAGEP AWVTQFVQKK EERDLVNRLK AEQARRKQRE ERLQQLQHRV QLKYAAKRLR
181 QEEEERENLL RLSREMLETG PEAERPEQLE SGEEELVLAE YESDEEKKVA SGVDEDEDDL
241 EEEHITKIYH CSRTHSQLAQ FVHEVKKSPF GKDVRLVSLG SRQNLCVNED VRSLGSVQLI
301 NNRCVDMQRS RHEKKKGAEE EKPKRRRQEK QAACPFYNHE QMGLLRDEAL AEVKDMEQLL
361 ALGKEARACP YYGSRLAIPA AQLVVLPYQM LLHAATRQAA GIRLQDQVVI IDEAHNLIDT
421 TTSMHSVEVS GSQLCQAHSQ LLQYMERYGK RLKAKNLMYL KQILYLLEKF VAVLGGNIKQ
481 NPNTQSLSQT GMELKTINDF LFQSQIDNIN LFKVQRYCEK SMISRKLFGF TERYGAVFSS
541 REQPKLAGFQ QFLQSLQPRT TEALAAPADE SQASVPQPAS PLMHIEGFLA ALTTANQDGR
601 VILSRQGSLS QSTLKFLLLN PAVHFAQVVK ECRAVVIAGG TMQPVSNFRQ QLLACAGVEA
661 ERVVEFSCGH VIPPDNILPL VICSGVSNQP LEFTFQKRDL PQMMDEVGRI LCNLCGVVSG
721 GVVCFFPSYE YLRQVHAHWE KGGLLGRLAA RKKIFQEPKS AHQVEQVLLA YSRCLQACGQ
781 ERGPVTGALL LSVVGGKMSE GINFSDNLGR CVVMVGMPFP NIRSAELQEK MAYLDQTLPR
841 APGQAHPGKA LVENLCMKAV NQSIGRAIRH QKDFASIVLL DQRYARPPVL AKLPAWIRAR
901 VEVKATFGPA IAAVQKVSPT FFFLRASQPR DHISHCLLSA QFHREKSASSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against DDX12P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.33
OntologyGO
Biological processes
Molecular functions
- ATP binding
- DNA binding
- DNA helicase activity
- hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
- iron-sulfur cluster binding
- metal ion binding
- RNA binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Helicase-like, DEXD box c2 type
- ATP-dependent helicase, C-terminal
- RAD3-like helicase, DEAD
- ATP-dependent helicase Rad3/Chl1-like
- Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type
- P-loop containing nucleoside triphosphate hydrolase
- Helicase superfamily 1/2, DinG/Rad3-like
- DEAD_2
- Helicase C-terminal domain
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads DDX12P as an antibody target. Whether an autoantibody or antibody against DDX12P could matter depends on whether native DDX12P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
DDX12P is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label DDX12P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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