Seroatlas · Human Serome Atlas

SEPTIN6

Septin-6

Also known as: KIAA0128, MGC16619, MGC20339, SEP2, SEPT2, SEPT6, SEPT6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14141
Gene
SEPTIN6
Ensembl
ENSG00000125354
Chromosome
X
Canonical length
434 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Primary cilium,Cytosol,Mid piece,Principal piece

OverviewNCBI Gene

This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

434 residues, UniProt reviewed canonical sequence.

>Q14141|SEPTIN6
     1  MAATDIARQV GEGCRTVPLA GHVGFDSLPD QLVNKSVSQG FCFNILCVGE TGLGKSTLMD
    61  TLFNTKFEGE PATHTQPGVQ LQSNTYDLQE SNVRLKLTIV STVGFGDQIN KEDSYKPIVE
   121  FIDAQFEAYL QEELKIRRVL HTYHDSRIHV CLYFIAPTGH SLKSLDLVTM KKLDSKVNII
   181  PIIAKADAIS KSELTKFKIK ITSELVSNGV QIYQFPTDDE SVAEINGTMN AHLPFAVIGS
   241  TEELKIGNKM MRARQYPWGT VQVENEAHCD FVKLREMLIR VNMEDLREQT HTRHYELYRR
   301  CKLEEMGFKD TDPDSKPFSL QETYEAKRNE FLGELQKKEE EMRQMFVQRV KEKEAELKEA
   361  EKELHEKFDR LKKLHQDEKK KLEDKKKSLD DEVNAFKQRK TAAELLQSQG SQAGGSQTLK
   421  RDKEKKNNPW LCTE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SEPTIN6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
216 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 216 nTPM
  • lymph node: 112 nTPM
  • tonsil: 97 nTPM
  • adrenal gland: 70 nTPM
  • appendix: 63 nTPM
  • spleen: 58 nTPM

Single-cell type

  • thymocytes: 522 nCPM
  • sertoli cells: 477 nCPM
  • hematopoietic stem cells: 396 nCPM
  • t-cells: 343 nCPM
  • innate lymphoid cells: 313 nCPM
  • platelets: 304 nCPM

Immune cell

  • T-reg: 113 nTPM
  • NK-cell: 82 nTPM
  • naive CD4 T-cell: 80 nTPM
  • memory CD4 T-cell: 76 nTPM
  • naive CD8 T-cell: 70 nTPM
  • memory CD8 T-cell: 69 nTPM

Brain region

  • pons: 45 nTPM
  • hypothalamus: 42 nTPM
  • thalamus: 41 nTPM
  • medulla oblongata: 36 nTPM
  • midbrain: 36 nTPM
  • cerebellum: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.5
gnomAD pLI
0.29
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SEPTIN6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SEPTIN6 as an antibody target. Whether an autoantibody or antibody against SEPTIN6 could matter depends on whether native SEPTIN6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SEPTIN6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SEPTIN6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SEPTIN6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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