Seroatlas · Human Serome Atlas

NMRK2

Nicotinamide riboside kinase 2

Also known as: ITGB1BP3, MIBP, NRK2, NRK2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NPI5
Gene: NMRK2
Ensembl: ENSG00000077009
Chromosome: 19
Canonical length: 230 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

Enables ribosylnicotinamide kinase activity and ribosylnicotinate kinase activity. Predicted to be involved in NAD metabolic process. Predicted to act upstream of or within negative regulation of myoblast differentiation. Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

230 residues, UniProt reviewed canonical sequence.

>Q9NPI5|NMRK2
     1  MKLIVGIGGM TNGGKTTLTN SLLRALPNCC VIHQDDFFKP QDQIAVGEDG FKQWDVLESL
    61  DMEAMLDTVQ AWLSSPQKFA RAHGVSVQPE ASDTHILLLE GFLLYSYKPL VDLYSRRYFL
   121  TVPYEECKWR RSTRNYTVPD PPGLFDGHVW PMYQKYRQEM EANGVEVVYL DGMKSREELF
   181  REVLEDIQNS LLNRSQESAP SPARPARTQG PGRGCGHRTA RPAASQQDSM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NMRK2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 1,378 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 1,378 nTPM
tongue: 669 nTPM
skeletal muscle: 591 nTPM
blood vessel: 9.9 nTPM
salivary gland: 7.1 nTPM
esophagus: 5.4 nTPM

Single-cell type

myonuclei: 165 nCPM
cardiomyocytes: 140 nCPM
oocytes: 138 nCPM
thymic myoid cells: 46 nCPM
retinal ganglion cells: 12 nCPM
vascular smooth muscle cells: 10 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 2 nTPM
hypothalamus: 1.3 nTPM
midbrain: 1.2 nTPM
spinal cord: 0.9 nTPM
thalamus: 0.9 nTPM
amygdala: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.93
gnomAD pLI: 0
gnomAD missense Z: -0.17
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NMRK2 as an antibody target. Whether an autoantibody or antibody against NMRK2 could matter depends on whether native NMRK2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NMRK2 is annotated at the cell surface, where native NMRK2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NMRK2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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