Seroatlas · Human Serome Atlas

RUVBL2

RuvB-like 2

Also known as: ECP51, INO80J, Reptin52, RUVB2_HUMAN, RVB2, TIH2, TIP48, TIP49b

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y230
Gene
RUVBL2
Ensembl
ENSG00000183207
Chromosome
19
Canonical length
463 aa
Protein class
Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Centrosome,Basal body,Cytosol

OverviewNCBI Gene

This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

463 residues, UniProt reviewed canonical sequence.

>Q9Y230|RUVBL2
     1  MATVTATTKV PEIRDVTRIE RIGAHSHIRG LGLDDALEPR QASQGMVGQL AARRAAGVVL
    61  EMIREGKIAG RAVLIAGQPG TGKTAIAMGM AQALGPDTPF TAIAGSEIFS LEMSKTEALT
   121  QAFRRSIGVR IKEETEIIEG EVVEIQIDRP ATGTGSKVGK LTLKTTEMET IYDLGTKMIE
   181  SLTKDKVQAG DVITIDKATG KISKLGRSFT RARDYDAMGS QTKFVQCPDG ELQKRKEVVH
   241  TVSLHEIDVI NSRTQGFLAL FSGDTGEIKS EVREQINAKV AEWREEGKAE IIPGVLFIDE
   301  VHMLDIESFS FLNRALESDM APVLIMATNR GITRIRGTSY QSPHGIPIDL LDRLLIVSTT
   361  PYSEKDTKQI LRIRCEEEDV EMSEDAYTVL TRIGLETSLR YAIQLITAAS LVCRKRKGTE
   421  VQVDDIKRVY SLFLDESRST QYMKEYQDAF LFNELKGETM DTS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RUVBL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
232 nTPM

Expression across tissuesHPA

Tissue

  • testis: 232 nTPM
  • skeletal muscle: 85 nTPM
  • fallopian tube: 68 nTPM
  • choroid plexus: 62 nTPM
  • esophagus: 57 nTPM
  • heart muscle: 52 nTPM

Single-cell type

  • late spermatids: 1,437 nCPM
  • late primary spermatocytes: 918 nCPM
  • early spermatids: 588 nCPM
  • fallopian tube ciliated cells: 301 nCPM
  • respiratory ciliated cells: 276 nCPM
  • epididymal efferent duct ciliated cells: 202 nCPM

Immune cell

  • myeloid DC: 66 nTPM
  • total PBMC: 55 nTPM
  • classical monocyte: 55 nTPM
  • memory B-cell: 55 nTPM
  • naive B-cell: 53 nTPM
  • intermediate monocyte: 52 nTPM

Brain region

  • white matter: 59 nTPM
  • choroid plexus: 54 nTPM
  • cerebral cortex: 49 nTPM
  • midbrain: 48 nTPM
  • hippocampal formation: 45 nTPM
  • cerebellum: 45 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.11
gnomAD pLI
1
gnomAD missense Z
3.11
DepMap mean gene effect
-1.87
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RUVBL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RUVBL2 as an antibody target. Whether an autoantibody or antibody against RUVBL2 could matter depends on whether native RUVBL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RUVBL2 is annotated at the cell surface, where native RUVBL2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RUVBL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RUVBL2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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