Seroatlas · Human Serome Atlas

CNP

2',3'-cyclic-nucleotide 3'-phosphodiesterase

Also known as: CN37_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P09543
Gene
CNP
Ensembl
ENSG00000173786
Chromosome
17
Canonical length
421 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location
Plasma membrane
Quaternary structure
Homodimer

OverviewNCBI Gene

Predicted to enable 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity. Involved in substantia nigra development. Located in cytoplasm; extracellular space; and microtubule. Implicated in hypomyelinating leukodystrophy 20; multiple sclerosis; and schizophrenia. Biomarker of alcoholic liver cirrhosis; multiple sclerosis; and restless legs syndrome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

421 residues, UniProt reviewed canonical sequence.

>P09543|CNP
     1  MNRGFSRKSH TFLPKIFFRK MSSSGAKDKP ELQFPFLQDE DTVATLLECK TLFILRGLPG
    61  SGKSTLARVI VDKYRDGTKM VSADAYKITP GARGAFSEEY KRLDEDLAAY CRRRDIRILV
   121  LDDTNHERER LEQLFEMADQ YQYQVVLVEP KTAWRLDCAQ LKEKNQWQLS ADDLKKLKPG
   181  LEKDFLPLYF GWFLTKKSSE TLRKAGQVFL EELGNHKAFK KELRQFVPGD EPREKMDLVT
   241  YFGKRPPGVL HCTTKFCDYG KAPGAEEYAQ QDVLKKSYSK AFTLTISALF VTPKTTGARV
   301  ELSEQQLQLW PSDVDKLSPT DNLPRGSRAH ITLGCAADVE AVQTGLDLLE ILRQEKGGSR
   361  GEEVGELSRG KLYSLGNGRW MLTLAKNMEV RAIFTGYYGK GKPVPTQGSR KGGALQSCTI
   421  I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CNP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
1,113 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 1,113 nTPM
  • midbrain: 536 nTPM
  • hippocampal formation: 500 nTPM
  • basal ganglia: 397 nTPM
  • cerebral cortex: 344 nTPM
  • amygdala: 319 nTPM

Single-cell type

  • oligodendrocytes: 843 nCPM
  • schwann cells: 198 nCPM
  • esophageal apical cells: 147 nCPM
  • esophageal suprabasal cells: 111 nCPM
  • oligodendrocyte progenitor cells: 82 nCPM
  • müller glia: 79 nCPM

Immune cell

  • plasmacytoid DC: 150 nTPM
  • intermediate monocyte: 41 nTPM
  • classical monocyte: 38 nTPM
  • non-classical monocyte: 34 nTPM
  • myeloid DC: 34 nTPM
  • total PBMC: 33 nTPM

Brain region

  • white matter: 2,517 nTPM
  • basal ganglia: 1,526 nTPM
  • medulla oblongata: 1,460 nTPM
  • thalamus: 1,340 nTPM
  • cerebral cortex: 1,307 nTPM
  • midbrain: 1,288 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CNP.

Disease | AllUniProt

Conditions CNP is implicated in, by any mechanism.

  • Leukodystrophy, hypomyelinating, 20 (HLD20) MIM:619071

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 72 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Myopia 2, autosomal dominant
  • Leukodystrophy, hypomyelinating, 20

Disease | ImmuneIEDB

Conditions an epitope on CNP was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.28
gnomAD pLI
0.98
gnomAD missense Z
2.43
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

  • RNA binding
  • 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CNP as an antibody target. Whether an autoantibody or antibody against CNP could matter depends on whether native CNP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CNP is annotated at the cell surface, where native CNP is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CNP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CNP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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