ARL5A
ADP-ribosylation factor-like protein 5A
Also known as: ARL5, ARL5A_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9Y689
- Gene
- ARL5A
- Ensembl
- ENSG00000162980
- Chromosome
- 2
- Canonical length
- 179 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
The protein encoded by this gene belongs to the ARF family of GTP-binding proteins. With its distinctive nuclear/nucleolar localization and interaction with HP1alpha, the protein is developmentally regulated and may play a role(s) in nuclear dynamics and/or signaling cascades during embryonic development. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
179 residues, UniProt reviewed canonical sequence.
>Q9Y689|ARL5A
1 MGILFTRIWR LFNHQEHKVI IVGLDNAGKT TILYQFSMNE VVHTSPTIGS NVEEIVINNT
61 RFLMWDIGGQ ESLRSSWNTY YTNTEFVIVV VDSTDRERIS VTREELYKML AHEDLRKAGL
121 LIFANKQDVK ECMTVAEISQ FLKLTSIKDH QWHIQACCAL TGEGLCQGLE WMMSRLKIRLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ARL5A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.28
- Highest tissue expression
- 34 nTPM
Expression across tissuesHPA
Tissue
- tongue: 34 nTPM
- heart muscle: 34 nTPM
- skeletal muscle: 31 nTPM
- thyroid gland: 28 nTPM
- skin: 27 nTPM
- kidney: 23 nTPM
Single-cell type
- microglia: 285 nCPM
- parietal cells: 147 nCPM
- gastric chief cells: 137 nCPM
- esophageal apical cells: 121 nCPM
- adrenal cortex cells: 117 nCPM
- enterocytes: 116 nCPM
Immune cell
- basophil: 89 nTPM
- naive B-cell: 15 nTPM
- myeloid DC: 11 nTPM
- memory B-cell: 11 nTPM
- eosinophil: 9 nTPM
- memory CD8 T-cell: 8.6 nTPM
Brain region
- medulla oblongata: 48 nTPM
- hypothalamus: 48 nTPM
- white matter: 48 nTPM
- spinal cord: 46 nTPM
- cerebellum: 43 nTPM
- pons: 40 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.8
- gnomAD pLI
- 0.13
- gnomAD missense Z
- 0.47
- DepMap mean gene effect
- 0.06
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ARL5A as an antibody target. Whether an autoantibody or antibody against ARL5A could matter depends on whether native ARL5A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ARL5A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ARL5A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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