Seroatlas · Human Serome Atlas

HNRNPUL2

Heterogeneous nuclear ribonucleoprotein U-like protein 2

Also known as: DKFZp762N1910, HNRL2_HUMAN, HNRPUL2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q1KMD3
Gene: HNRNPUL2
Ensembl: ENSG00000214753
Chromosome: 11
Canonical length: 747 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be involved in alternative mRNA splicing, via spliceosome. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

747 residues, UniProt reviewed canonical sequence.

>Q1KMD3|HNRNPUL2
     1  MEVKRLKVTE LRSELQRRGL DSRGLKVDLA QRLQEALDAE MLEDEAGGGG AGPGGACKAE
    61  PRPVAASGGG PGGDEEEDEE EEEEDEEALL EDEDEEPPPA QALGQAAQPP PEPPEAAAME
   121  AAAEPDASEK PAEATAGSGG VNGGEEQGLG KREEDEPEER SGDETPGSEV PGDKAAEEQG
   181  DDQDSEKSKP AGSDGERRGV KRQRDEKDEH GRAYYEFREE AYHSRSKSPL PPEEEAKDEE
   241  EDQTLVNLDT YTSDLHFQVS KDRYGGQPLF SEKFPTLWSG ARSTYGVTKG KVCFEAKVTQ
   301  NLPMKEGCTE VSLLRVGWSV DFSRPQLGED EFSYGFDGRG LKAENGQFEE FGQTFGENDV
   361  IGCFANFETE EVELSFSKNG EDLGVAFWIS KDSLADRALL PHVLCKNCVV ELNFGQKEEP
   421  FFPPPEEFVF IHAVPVEERV RTAVPPKTIE ECEVILMVGL PGSGKTQWAL KYAKENPEKR
   481  YNVLGAETVL NQMRMKGLEE PEMDPKSRDL LVQQASQCLS KLVQIASRTK RNFILDQCNV
   541  YNSGQRRKLL LFKTFSRKVV VVVPNEEDWK KRLELRKEVE GDDVPESIML EMKANFSLPE
   601  KCDYMDEVTY GELEKEEAQP IVTKYKEEAR KLLPPSEKRT NRRNNRNKRN RQNRSRGQGY
   661  VGGQRRGYDN RAYGQQYWGQ PGNRGGYRNF YDRYRGDYDR FYGRDYEYNR YRDYYRQYNR
   721  DWQSYYYHHP QDRDRYYRNY YGYQGYR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HNRNPUL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 57 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 57 nTPM
cerebral cortex: 49 nTPM
skeletal muscle: 46 nTPM
basal ganglia: 45 nTPM
thymus: 44 nTPM
amygdala: 40 nTPM

Single-cell type

megakaryocyte progenitors: 10 nCPM
erythrocyte progenitors: 8.2 nCPM
monocyte progenitors: 5.1 nCPM
late primary spermatocytes: 5 nCPM
smooth muscle cells: 4.2 nCPM
megakaryocyte-erythroid progenitors: 3.7 nCPM

Immune cell

gdT-cell: 1.4 nTPM
non-classical monocyte: 1.4 nTPM
plasmacytoid DC: 1.4 nTPM
eosinophil: 1.3 nTPM
naive B-cell: 1.3 nTPM
memory CD8 T-cell: 1.2 nTPM

Brain region

cerebellum: 45 nTPM
thalamus: 43 nTPM
basal ganglia: 41 nTPM
cerebral cortex: 40 nTPM
amygdala: 39 nTPM
midbrain: 38 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HNRNPUL2.

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 116 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.23
gnomAD pLI: 1
gnomAD missense Z: 0.96
DepMap mean gene effect: -0.22
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

via spliceosome
alternative mRNA splicing

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HNRNPUL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HNRNPUL2 as an antibody target. Whether an autoantibody or antibody against HNRNPUL2 could matter depends on whether native HNRNPUL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HNRNPUL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HNRNPUL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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