Seroatlas · Human Serome Atlas

CACNB3

Voltage-dependent L-type calcium channel subunit beta-3

Also known as: CACB3_HUMAN, CACNLB3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P54284
Gene
CACNB3
Ensembl
ENSG00000167535
Chromosome
12
Canonical length
484 aa
Protein class
FDA approved drug targets, Predicted intracellular proteins, Transporters
Subcellular location
Golgi apparatus,Vesicles

OverviewNCBI Gene

This gene encodes a regulatory beta subunit of the voltage-dependent calcium channel. Beta subunits are composed of five domains, which contribute to the regulation of surface expression and gating of calcium channels and may also play a role in the regulation of transcription factors and calcium transport. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

484 residues, UniProt reviewed canonical sequence.

>P54284|CACNB3
     1  MYDDSYVPGF EDSEAGSADS YTSRPSLDSD VSLEEDRESA RREVESQAQQ QLERAKHKPV
    61  AFAVRTNVSY CGVLDEECPV QGSGVNFEAK DFLHIKEKYS NDWWIGRLVK EGGDIAFIPS
   121  PQRLESIRLK QEQKARRSGN PSSLSDIGNR RSPPPSLAKQ KQKQAEHVPP YDVVPSMRPV
   181  VLVGPSLKGY EVTDMMQKAL FDFLKHRFDG RISITRVTAD LSLAKRSVLN NPGKRTIIER
   241  SSARSSIAEV QSEIERIFEL AKSLQLVVLD ADTINHPAQL AKTSLAPIIV FVKVSSPKVL
   301  QRLIRSRGKS QMKHLTVQMM AYDKLVQCPP ESFDVILDEN QLEDACEHLA EYLEVYWRAT
   361  HHPAPGPGLL GPPSAIPGLQ NQQLLGERGE EHSPLERDSL MPSDEASESS RQAWTGSSQR
   421  SSRHLEEDYA DAYQDLYQPH RQHTSGLPSA NGHDPQDRLL AQDSEHNHSD RNWQRNRPWP
   481  KDSY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CACNB3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
75 nTPM

Expression across tissuesHPA

Tissue

  • amygdala: 75 nTPM
  • cerebral cortex: 73 nTPM
  • hippocampal formation: 50 nTPM
  • cerebellum: 49 nTPM
  • ovary: 43 nTPM
  • basal ganglia: 42 nTPM

Single-cell type

  • respiratory ionocytes: 38 nCPM
  • decidual stromal cells: 32 nCPM
  • ovarian stromal cells: 29 nCPM
  • fallopian tube ciliated cells: 24 nCPM
  • esophageal suprabasal cells: 24 nCPM
  • tuft cells: 23 nCPM

Immune cell

  • T-reg: 1.8 nTPM
  • memory CD4 T-cell: 0.6 nTPM
  • memory CD8 T-cell: 0.6 nTPM
  • gdT-cell: 0.3 nTPM
  • total PBMC: 0.2 nTPM
  • classical monocyte: 0.1 nTPM

Brain region

  • cerebral cortex: 66 nTPM
  • amygdala: 55 nTPM
  • basal ganglia: 54 nTPM
  • hippocampal formation: 41 nTPM
  • hypothalamus: 37 nTPM
  • white matter: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.64
gnomAD pLI
0
gnomAD missense Z
2.17
DepMap mean gene effect
-0.39
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CACNB3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CACNB3 as an antibody target. Whether an autoantibody or antibody against CACNB3 could matter depends on whether native CACNB3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CACNB3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CACNB3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CACNB3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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