Seroatlas · Human Serome Atlas

HELQ

Helicase POLQ-like

Also known as: Hel308, HELQ_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TDG4
Gene: HELQ
Ensembl: ENSG00000163312
Chromosome: 4
Canonical length: 1101 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear speckles
Quaternary structure: Homodimer

OverviewNCBI Gene

HEL308 is a single-stranded DNA-dependent ATPase and DNA helicase (Marini and Wood, 2002 [PubMed 11751861]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

1101 residues, UniProt reviewed canonical sequence.

>Q8TDG4|HELQ
     1  MDECGSRIRR RVSLPKRNRP SLGCIFGAPT AAELVPGDEG KEEEEMVAEN RRRKTAGVLP
    61  VEVQPLLLSD SPECLVLGGG DTNPDLLRHM PTDRGVGDQP NDSEVDMFGD YDSFTENSFI
   121  AQVDDLEQKY MQLPEHKKHA TDFATENLCS ESIKNKLSIT TIGNLTELQT DKHTENQSGY
   181  EGVTIEPGAD LLYDVPSSQA IYFENLQNSS NDLGDHSMKE RDWKSSSHNT VNEELPHNCI
   241  EQPQQNDESS SKVRTSSDMN RRKSIKDHLK NAMTGNAKAQ TPIFSRSKQL KDTLLSEEIN
   301  VAKKTVESSS NDLGPFYSLP SKVRDLYAQF KGIEKLYEWQ HTCLTLNSVQ ERKNLIYSLP
   361  TSGGKTLVAE ILMLQELLCC RKDVLMILPY VAIVQEKISG LSSFGIELGF FVEEYAGSKG
   421  RFPPTKRREK KSLYIATIEK GHSLVNSLIE TGRIDSLGLV VVDELHMIGE GSRGATLEMT
   481  LAKILYTSKT TQIIGMSATL NNVEDLQKFL QAEYYTSQFR PVELKEYLKI NDTIYEVDSK
   541  AENGMTFSRL LNYKYSDTLK KMDPDHLVAL VTEVIPNYSC LVFCPSKKNC ENVAEMICKF
   601  LSKEYLKHKE KEKCEVIKNL KNIGNGNLCP VLKRTIPFGV AYHHSGLTSD ERKLLEEAYS
   661  TGVLCLFTCT STLAAGVNLP ARRVILRAPY VAKEFLKRNQ YKQMIGRAGR AGIDTIGESI
   721  LILQEKDKQQ VLELITKPLE NCYSHLVQEF TKGIQTLFLS LIGLKIATNL DDIYHFMNGT
   781  FFGVQQKVLL KEKSLWEITV ESLRYLTEKG LLQKDTIYKS EEEVQYNFHI TKLGRASFKG
   841  TIDLAYCDIL YRDLKKGLEG LVLESLLHLI YLTTPYDLVS QCNPDWMIYF RQFSQLSPAE
   901  QNVAAILGVS ESFIGKKASG QAIGKKVDKN VVNRLYLSFV LYTLLKETNI WTVSEKFNMP
   961  RGYIQNLLTG TASFSSCVLH FCEELEEFWV YRALLVELTK KLTYCVKAEL IPLMEVTGVL
  1021  EGRAKQLYSA GYKSLMHLAN ANPEVLVRTI DHLSRRQAKQ IVSSAKMLLH EKAEALQEEV
  1081  EELLRLPSDF PGAVASSTDK A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HELQ can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 8.7 nTPM

Expression across tissuesHPA

Tissue

lymph node: 8.7 nTPM
adrenal gland: 8.4 nTPM
tongue: 7.6 nTPM
thymus: 7.4 nTPM
tonsil: 7.1 nTPM
ovary: 7 nTPM

Single-cell type

adrenal cortex cells: 145 nCPM
b-cells: 60 nCPM
myonuclei: 59 nCPM
microglia: 50 nCPM
neutrophil progenitors: 49 nCPM
thymocytes: 48 nCPM

Immune cell

naive CD4 T-cell: 5.6 nTPM
naive B-cell: 5.1 nTPM
naive CD8 T-cell: 4.8 nTPM
T-reg: 4.5 nTPM
eosinophil: 3.6 nTPM
NK-cell: 3.6 nTPM

Brain region

choroid plexus: 10 nTPM
cerebellum: 8.5 nTPM
white matter: 6.2 nTPM
basal ganglia: 5.5 nTPM
pons: 5.3 nTPM
spinal cord: 5.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HELQ.

Disease | ImmuneIEDB

Conditions an epitope on HELQ was assayed in.

ankylosing spondylitis T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.76
gnomAD pLI: 0
gnomAD missense Z: 0.6
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HELQ in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HELQ as an antibody target. Whether an autoantibody or antibody against HELQ could matter depends on whether native HELQ is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HELQ is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HELQ as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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