Seroatlas · Human Serome Atlas

RAB6D

Ras-related protein Rab-6D

Also known as: RAB6CL, RAB6D_HUMAN, WTH3DI

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q53S08
Gene
RAB6D
Ensembl
ENSG00000233087
Chromosome
2
Canonical length
254 aa
Protein class
Predicted intracellular proteins
Subcellular location
Golgi apparatus,Basal body

OverviewNCBI Gene

Predicted to enable GTPase activity. Predicted to be involved in several processes, including Golgi vesicle transport; protein localization to Golgi membrane; and retrograde transport, endosome to Golgi. Located in Golgi apparatus; ciliary basal body; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

254 residues, UniProt reviewed canonical sequence.

>Q53S08|RAB6D
     1  MSAGGDFGNP LRKFKLVFLG EQSVAKTSLI TRFRYDSFDN TYQAIIGIDF LSKTMYLEDG
    61  TIGLRLWDTA GQERLRSLIP RYIRDSAAAV VVYDITNVNS FQQTTKWIDD VRTEGGSDVI
   121  ITLVGNKTDL ADKRQVSIEE GERKAKGLNV TFIETRAKAG YNVKQLFRRV AAALPGMEST
   181  QDGSREDMSD IKLEKPQEQT VSEGGCSCYS PMSSSTLPQK PPYSFIDCSV NIGLNLFPSL
   241  ITFCNSSLLP VSWR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB6D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
6.6 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 6.6 nTPM
  • prostate: 1.7 nTPM
  • hypothalamus: 0.9 nTPM
  • testis: 0.9 nTPM
  • cerebral cortex: 0.8 nTPM
  • colon: 0.8 nTPM

Single-cell type

  • paneth cells: 3.9 nCPM
  • early primary spermatocytes: 3.5 nCPM
  • prostatic glandular cells: 2.3 nCPM
  • colonocytes: 1.5 nCPM
  • neuroendocrine cells: 1.5 nCPM
  • gastric progenitor cells: 1.3 nCPM

Immune cell

  • basophil: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 3.5 nTPM
  • hypothalamus: 3.3 nTPM
  • basal ganglia: 2.8 nTPM
  • hippocampal formation: 2.7 nTPM
  • white matter: 2.6 nTPM
  • pons: 2.4 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB6D as an antibody target. Whether an autoantibody or antibody against RAB6D could matter depends on whether native RAB6D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB6D is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RAB6D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RAB6D. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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