Seroatlas · Human Serome Atlas

RHOV

Rho-related GTP-binding protein RhoV

Also known as: ARHV, Chp, RHOV_HUMAN, WRCH2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96L33
Gene: RHOV
Ensembl: ENSG00000104140
Chromosome: 15
Canonical length: 236 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including actin filament organization; endocytosis; and establishment of cell polarity. Predicted to be located in endosome membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

236 residues, UniProt reviewed canonical sequence.

>Q96L33|RHOV
     1  MPPRELSEAE PPPLRAPTPP PRRRSAPPEL GIKCVLVGDG AVGKSSLIVS YTCNGYPARY
    61  RPTALDTFSV QVLVDGAPVR IELWDTAGQE DFDRLRSLCY PDTDVFLACF SVVQPSSFQN
   121  ITEKWLPEIR THNPQAPVLL VGTQADLRDD VNVLIQLDQG GREGPVPQPQ AQGLAEKIRA
   181  CCYLECSALT QKNLKEVFDS AILSAIEHKA RLEKKLNAKG VRTLSRCRWK KFFCFV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RHOV can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 210 nTPM

Expression across tissuesHPA

Tissue

esophagus: 210 nTPM
skin: 129 nTPM
vagina: 93 nTPM
cervix: 65 nTPM
salivary gland: 44 nTPM
tonsil: 22 nTPM

Single-cell type

esophageal apical cells: 891 nCPM
esophageal suprabasal cells: 830 nCPM
esophageal basal cells: 534 nCPM
submucosal glandular cells: 319 nCPM
suprabasal keratinocytes: 299 nCPM
prostatic club cells: 236 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 4.4 nTPM
hypothalamus: 3.3 nTPM
medulla oblongata: 2.2 nTPM
cerebral cortex: 2.1 nTPM
cerebellum: 1.6 nTPM
basal ganglia: 1.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.52
gnomAD pLI: 0.76
gnomAD missense Z: 1.95
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RHOV in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PAK2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RHOV as an antibody target. Whether an autoantibody or antibody against RHOV could matter depends on whether native RHOV is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RHOV is annotated at the cell surface, where native RHOV is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RHOV as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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