AGAP1

Protein identityUniProt · HPA

UniProt accession

Q9UPQ3

Gene

AGAP1

Ensembl

ENSG00000157985

Chromosome

2

Canonical length

857 aa

Protein class

Plasma proteins, Predicted intracellular proteins

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a member of an ADP-ribosylation factor GTPase-activating protein family involved in membrane trafficking and cytoskeleton dynamics. This gene functions as a direct regulator of the adaptor-related protein complex 3 on endosomes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

857 residues, UniProt reviewed canonical sequence.

>Q9UPQ3|AGAP1
     1  MNYQQQLANS AAIRAEIQRF ESVHPNIYSI YELLERVEEP VLQNQIREHV IAIEDAFVNS
    61  QEWTLSRSVP ELKVGIVGNL ASGKSALVHR YLTGTYVQEE SPEGGRFKKE IVVDGQSYLL
   121  LIRDEGGPPE AQFAMWVDAV IFVFSLEDEI SFQTVYHYYS RMANYRNTSE IPLVLVGTQD
   181  AISSANPRVI DDARARKLSN DLKRCTYYET CATYGLNVER VFQDVAQKIV ATRKKQQLSI
   241  GPCKSLPNSP SHSSVCSAQV SAVHISQTSN GGGSLSDYSS SVPSTPSTSQ KELRIDVPPT
   301  ANTPTPVRKQ SKRRSNLFTS RKGSDPDKEK KGLESRADSI GSGRAIPIKQ GMLLKRSGKS
   361  LNKEWKKKYV TLCDNGVLTY HPSLHDYMQN VHGKEIDLLR TTVKVPGKRP PRATSACAPI
   421  SSPKTNGLSK DMSSLHISPN SGNVTSASGS QMASGISLVS FNSRPDGMHQ RSYSVSSADQ
   481  WSEATVIANS AISSDTGLGD SVCSSPSISS TTSPKLDPPP SPHANRKKHR RKKSTSNFKA
   541  DGLSGTAEEQ EENFEFIIVS LTGQTWHFEA TTYEERDAWV QAIESQILAS LQSCESSKNK
   601  SRLTSQSEAM ALQSIRNMRG NSHCVDCETQ NPNWASLNLG ALMCIECSGI HRNLGTHLSR
   661  VRSLDLDDWP VELIKVMSSI GNELANSVWE ESSQGRTKPS VDSTREEKER WIRAKYEQKL
   721  FLAPLPCTEL SLGQHLLRAT ADEDLRTAIL LLAHGSRDEV NETCGEGDGR TALHLACRKG
   781  NVVLAQLLIW YGVDVTARDA HGNTALAYAR QASSQECIDV LLQYGCPDER FVLMATPNLS
   841  RRNNNRNNSS GRVPTII

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AGAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.42

Highest tissue expression

44 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.23

gnomAD pLI

1

gnomAD missense Z

1.29

DepMap mean gene effect

0.07

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• protein transport
• regulation of modification of postsynaptic structure

Molecular functions

• GTP binding
• GTPase activator activity
• GTPase activity
• phospholipid binding
• zinc ion binding

Cellular components

• postsynaptic endosome

Protein domainsUniProt · Pfam · InterPro

• Arf GTPase activating protein
• Small GTPase
• Pleckstrin homology domain
• Ankyrin repeat
• PH-like domain superfamily
• P-loop containing nucleoside triphosphate hydrolase
• Ankyrin repeat-containing domain superfamily
• ARFGAP/RecO-like zinc finger
• ArfGAP domain superfamily
• Arf-GAP with GTPase, ANK repeat and PH domain-containing protein
• Ras family
• Putative GTPase activating protein for Arf
• Ankyrin repeats (3 copies)

KeywordsUniProt

• Acetylation
• ANK repeat
• Cytoplasm
• GTP-binding
• GTPase activation
• Metal-binding
• Nucleotide-binding
• Phosphoprotein
• Protein transport
• Repeat
• Transport
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of AGAP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• AP3S1
• AP3S2
• GUCY1A3
• GUCY1B3
• AP3M1