Seroatlas · Human Serome Atlas

ABCF1

ATP-binding cassette sub-family F member 1

Also known as: ABC50, ABCF1_HUMAN, EST123147

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NE71
Gene: ABCF1
Ensembl: ENSG00000204574
Chromosome: 6
Canonical length: 845 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transporters
Subcellular location: Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the GCN20 subfamily. Unlike other members of the superfamily, this protein lacks the transmembrane domains which are characteristic of most ABC transporters. This protein may be regulated by tumor necrosis factor-alpha and play a role in enhancement of protein synthesis and the inflammation process. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

845 residues, UniProt reviewed canonical sequence.

>Q8NE71|ABCF1
     1  MPKAPKQQPP EPEWIGDGES TSPSDKVVKK GKKDKKIKKT FFEELAVEDK QAGEEEKVLK
    61  EKEQQQQQQQ QQQKKKRDTR KGRRKKDVDD DGEEKELMER LKKLSVPTSD EEDEVPAPKP
   121  RGGKKTKGGN VFAALIQDQS EEEEEEEKHP PKPAKPEKNR INKAVSEEQQ PALKGKKGKE
   181  EKSKGKAKPQ NKFAALDNEE EDKEEEIIKE KEPPKQGKEK AKKAEQGSEE EGEGEEEEEE
   241  GGESKADDPY AHLSKKEKKK LKKQMEYERQ VASLKAANAA ENDFSVSQAE MSSRQAMLEN
   301  ASDIKLEKFS ISAHGKELFV NADLYIVAGR RYGLVGPNGK GKTTLLKHIA NRALSIPPNI
   361  DVLLCEQEVV ADETPAVQAV LRADTKRLKL LEEERRLQGQ LEQGDDTAAE RLEKVYEELR
   421  ATGAAAAEAK ARRILAGLGF DPEMQNRPTQ KFSGGWRMRV SLARALFMEP TLLMLDEPTN
   481  HLDLNAVIWL NNYLQGWRKT LLIVSHDQGF LDDVCTDIIH LDAQRLHYYR GNYMTFKKMY
   541  QQKQKELLKQ YEKQEKKLKE LKAGGKSTKQ AEKQTKEALT RKQQKCRRKN QDEESQEAPE
   601  LLKRPKEYTV RFTFPDPPPL SPPVLGLHGV TFGYQGQKPL FKNLDFGIDM DSRICIVGPN
   661  GVGKSTLLLL LTGKLTPTHG EMRKNHRLKI GFFNQQYAEQ LRMEETPTEY LQRGFNLPYQ
   721  DARKCLGRFG LESHAHTIQI CKLSGGQKAR VVFAELACRE PDVLILDEPT NNLDIESIDA
   781  LGEAINEYKG AVIVVSHDAR LITETNCQLW VVEEQSVSQI DGDFEDYKRE VLEALGEVMV
   841  SRPRE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ABCF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 91 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 91 nTPM
skin: 35 nTPM
testis: 31 nTPM
heart muscle: 31 nTPM
endometrium: 29 nTPM
liver: 29 nTPM

Single-cell type

late spermatids: 152 nCPM
late primary spermatocytes: 142 nCPM
syncytiotrophoblasts: 127 nCPM
extravillous trophoblasts: 104 nCPM
differentiating spermatogonia: 84 nCPM
migrating cytotrophoblasts: 77 nCPM

Immune cell

memory CD8 T-cell: 10 nTPM
gdT-cell: 10 nTPM
MAIT T-cell: 9.3 nTPM
NK-cell: 8 nTPM
memory CD4 T-cell: 7.3 nTPM
naive CD4 T-cell: 6.3 nTPM

Brain region

white matter: 11 nTPM
medulla oblongata: 11 nTPM
thalamus: 10 nTPM
basal ganglia: 9.9 nTPM
pons: 9.9 nTPM
hypothalamus: 9.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.61
gnomAD pLI: 0
gnomAD missense Z: 2.51
DepMap mean gene effect: -0.9
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ABCF1 as an antibody target. Whether an autoantibody or antibody against ABCF1 could matter depends on whether native ABCF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ABCF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ABCF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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