Seroatlas · Human Serome Atlas

PSMC6

26S proteasome regulatory subunit 10B

Also known as: p42, PRS10_HUMAN, RPT5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P62333
Gene
PSMC6
Ensembl
ENSG00000100519
Chromosome
14
Canonical length
389 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

389 residues, UniProt reviewed canonical sequence.

>P62333|PSMC6
     1  MADPRDKALQ DYRKKLLEHK EIDGRLKELR EQLKELTKQY EKSENDLKAL QSVGQIVGEV
    61  LKQLTEEKFI VKATNGPRYV VGCRRQLDKS KLKPGTRVAL DMTTLTIMRY LPREVDPLVY
   121  NMSHEDPGNV SYSEIGGLSE QIRELREVIE LPLTNPELFQ RVGIIPPKGC LLYGPPGTGK
   181  TLLARAVASQ LDCNFLKVVS SSIVDKYIGE SARLIREMFN YARDHQPCII FMDEIDAIGG
   241  RRFSEGTSAD REIQRTLMEL LNQMDGFDTL HRVKMIMATN RPDTLDPALL RPGRLDRKIH
   301  IDLPNEQARL DILKIHAGPI TKHGEIDYEA IVKLSDGFNG ADLRNVCTEA GMFAIRADHD
   361  FVVQEDFMKA VRKVADSKKL ESKLDYKPV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSMC6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
129 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 129 nTPM
  • tongue: 100 nTPM
  • liver: 81 nTPM
  • heart muscle: 74 nTPM
  • tonsil: 63 nTPM
  • esophagus: 62 nTPM

Single-cell type

  • esophageal apical cells: 608 nCPM
  • syncytiotrophoblasts: 301 nCPM
  • cytotrophoblasts: 190 nCPM
  • migrating cytotrophoblasts: 183 nCPM
  • extravillous trophoblasts: 174 nCPM
  • esophageal suprabasal cells: 146 nCPM

Immune cell

  • T-reg: 86 nTPM
  • basophil: 78 nTPM
  • total PBMC: 75 nTPM
  • myeloid DC: 74 nTPM
  • non-classical monocyte: 73 nTPM
  • intermediate monocyte: 72 nTPM

Brain region

  • white matter: 35 nTPM
  • hypothalamus: 32 nTPM
  • pons: 32 nTPM
  • spinal cord: 32 nTPM
  • cerebral cortex: 31 nTPM
  • midbrain: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.25
gnomAD pLI
1
gnomAD missense Z
3.32
DepMap mean gene effect
-1.86
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PSMC6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSMC6 as an antibody target. Whether an autoantibody or antibody against PSMC6 could matter depends on whether native PSMC6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSMC6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PSMC6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PSMC6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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