STARD9

Protein identityUniProt · HPA

UniProt accession

Q9P2P6

Gene

STARD9

Ensembl

ENSG00000159433

Chromosome

15

Canonical length

4700 aa

Protein class

Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

Enables microtubule binding activity and microtubule motor activity. Involved in spindle assembly. Located in centriole; cytoplasm; and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

4700 residues, UniProt reviewed canonical sequence.

>Q9P2P6|STARD9
     1  MANVQVAVRV RPLSKRETKE GGRIIVEVDG KVAKIRNLKV DNRPDGFGDS REKVMAFGFD
    61  YCYWSVNPED PQYASQDVVF QDLGMEVLSG VAKGYNICLF AYGQTGSGKT YTMLGTPASV
   121  GLTPRICEGL FVREKDCASL PSSCRIKVSF LEIYNERVRD LLKQSGQKKS YTLRVREHPE
   181  MGPYVQGLSQ HVVTNYKQVI QLLEEGIANR ITAATHVHEA SSRSHAIFTI HYTQAILENN
   241  LPSEMASKIN LVDLAGSERA DPSYCKDRIA EGANINKSLV TLGIVISTLA QNSQVFSSCQ
   301  SLNSSVSNGG DSGILSSPSG TSSGGAPSRR QSYIPYRDSV LTWLLKDSLG GNSKTIMVAT
   361  VSPAHTSYSE TMSTLRYASS AKNIINKPRV NEDANLKLIR ELREEIERLK ALLLSFELRN
   421  FSSLSDENLK ELVLQNELKI DQLTKDWTQK WNDWQALMEH YSVDINRRRA GVVIDSSLPH
   481  LMALEDDVLS TGVVLYHLKE GTTKIGRIDS DQEQDIVLQG QWIERDHCTI TSACGVVVLR
   541  PARGARCTVN GREVTASCRL TQGAVITLGK AQKFRFNHPA EAAVLRQRRQ VGEAAAGRGS
   601  LEWLDLDGDL AASRLGLSPL LWKERRALEE QCDEDHQTPR DGETSHRAQI QQQQSYVEDL
   661  RHQILAEEIR AAKELEFDQA WISQQIKENQ QCLLREETWL ASLQQQQQED QVAEKELEAS
   721  VALDAWLQTD PEIQPSPFVQ SQKRVVHLQL LRRHTLRAAE RNVRRKKVSF QLERIIKKQR
   781  LLEAQKRLEK LTTLCWLQDD STQEPPYQVL SPDATVPRPP CRSKLTSCSS LSPQRLCSKH
   841  MPQLHSIFLS WDPSTTLPPR PDPTHQTSEK TSSEEHLPQA ASYPARTGCL RKNGLHSSGH
   901  GQPCTARAAL ARKGASAPDA CLTMSPNSVG IQEMEMGVKQ PHQMVSQGLA SLRKSANKLK
   961  PRHEPKIFTS TTQTRGAKGL ADPSHTQAGW RKEGNLGTHK AAKGASCNSL YPHGPRQTAG
  1021  HGKAVKTFWT EYKPPSPSRA SKRHQRVLAT RVRNITKKSS HLPLGSPLKR QQNTRDPDTM
  1081  VPLTDFSPVM DHSREKDNDL SDTDSNYSLD SLSCVYAKAL IEPLKPEERK WDFPEPENSE
  1141  SDDSQLSEDS LAEKRYQSPK NRLGGNRPTN NRGQPRTRTR ASVRGFTAAS DSDLLAQTHR
  1201  SFSLDSLIDA EEELGEDQQE EPFPGSADEI PTETFWHLED SSLPVMDQEA ICRLGPINYR
  1261  TAARLDAVLP MSSSFYLDPQ FQPHCELQPH CELQPHCELQ PHCEQAESQV EPSYSEQADS
  1321  LQGMQLSRES PLMSMDSWFS CDSKINPSSP PGIVGSLCPS PDMQEFHSCK GERPGYWPNT
  1381  EELKPSDAET VLPYSSKLHQ GSTELLCSAR DEHTASAADT SRLSLWGIQR LIQPGADGTF
  1441  QGRCIPDMTQ QGSSEASHNS SVSNVLAASA TTLTHVGSTH ERDWSALQQK YLLELSCPVL
  1501  EAIGAPKPAY PYLEEDSGSL AQASSKGGDT LLPVGPRVSS NLNLNNFPVH LSRIRRLRAE
  1561  KEQDSLNAKL EGVSDFFSTS EKEASYDETY SADLESLSAS RSTNAQVFAT ENAIPDSMTE
  1621  ACEVKQNNLE ECLQSCRKPG LMTSSDEDFF QKNACHSNVT TATKADHWSQ GWAPLRKNSA
  1681  VQPGQLSPDS HYPLEEEKTD CQESSKEAVR RHINVSFALP SGPELYLHSA PWNPLSSSLQ
  1741  PPLLETFYVT KSRDALTETA LEIPACREVR VPSPPPREAW GFGHNHQALQ GAYLKNNLPV
  1801  LLQNQNSKIA SSQQVTAEIP VDLNTREVIR ESGKCPGNIT EESHDSVYSS VTQNRHFLPS
  1861  TSTKVCEFEN QVVILNKKHS FPALEGGEVT AQSCCGASSD STESGKSLLF RESEAREEEE
  1921  LDQNTVLRQT INVSLEKDMP GESAVSLKSR SVDRRVSSPV MVAQGGGPTP KWEGKNETGL
  1981  LEKGLRPKDS SEEFKLPGTK PAYERFQLVA CPQERNPSEC KSQEMLNPNR EPSGKKQNKR
  2041  VNNTDEMARL IRSVMQLENG ILEIESKQNK QVHASHTPGT DKELVFQDQK EQEKTDHAFR
  2101  PDSSGNPLPS KDQPSSPRQT DDTVFRDSEA GAMEVNSIGN HPQVQKITPN PFRSREGVRE
  2161  SEPVREHTHP AGSDRPARDI CDSLGKHTTC REFTNTSLHP QRMKALARAL PLQPRLERSS
  2221  KNNGQFVKAS ASLKGQPWGL GSLEELETVK GFQESQVAEH VSSSNQEEPK AQGKVEEMPM
  2281  QRGGSLQEEN KVTQKFPSLS QLCRDTFFRQ ETVSPLLSRT EFCTAPLHQD LSNTLPLNSP
  2341  RWPRRCLHVP VALGISSLDC VLDLTMLKIH NSPLVTGVEH QDQSTETRSH SPEGNVRGRS
  2401  SEAHTAWCGS VRSMAMGSHS QSGVPESIPL GTEDRISAST SPQDHGKDLR ITLLGFSTSE
  2461  DFASEAEVAV QKEIRVSSLN KVSSQPEKRV SFSLEEDSDQ ASKPRQKAEK ETEDVGLTSG
  2521  VSLAPVSLPR VPSPEPRLLE PSDHASMCLA ILEEIRQAKA QRKQLHDFVA RGTVLSYCET
  2581  LLEPECSSRV AGRPQCKQID QSSSDQTRNE GEAPGFHVAS LSAEAGQIDL LPDERKVQAT
  2641  SLSADSFESL PNTETDREPW DPVQAFSHAA PAQDRKRRTG ELRQFAGASE PFICHSSSSE
  2701  IIEKKKDATR TPSSADPLAP DSPRSSAPVE EVRRVVSKKV VAALPSQAPY DDPRVTLHEL
  2761  SQSVPQETAE GIPPGSQDSS PEHQEPRTLD TTYGEVSDNL LVTAQGEKTA HFESQSVTCD
  2821  VQNSTSASGP KQDHVQCPEA STGFEEGRAS PKQDTILPGA LTRVALEAPT QQCVQCKESV
  2881  GSGLTEVCRA GSKHSRPIPL PDQRPSANPG GIGEEAPCRH PREALDGPVF SRNPEGSRTL
  2941  SPSRGKESRT LPCRQPCSSQ PVATHAYSSH SSTLLCFRDG DLGKEPFKAA PHTIHPPCVV
  3001  PSRAYEMDET GEISRGPDVH LTHGLEPKDV NREFRLTESS TCEPSTVAAV LSRAQGCRSP
  3061  SAPDVRTGSF SHSATDGSVG LIGVPEKKVA EKQASTELEA ASFPAGMYSE PLRQFRDSSV
  3121  GDQNAQVCQT NPEPPATTQG PHTLDLSEGS AESKLVVEPQ HECLENTTRC FLEKPQFSTE
  3181  LRDHNRLDSQ AKFVARLKHT CSPQEDSPWQ EEEQHRDQAS GGGEGFAQGV NPLPDEDGLD
  3241  GCQILDAGRE EVAVAKPPVS KILSQGFKDP ATVSLRQNET PQPAAQRSGH LYTGREQPAP
  3301  NHRGSLPVTT IFSGPKHSRS SPTPQFSVVG SSRSLQELNL SVEPPSPTDE DTQGPNRLWN
  3361  PHLRGYSSGK SVARTSLQAE DSNQKASSRL DDGTTDHRHL KPATPPYPMP STLSHMPTPD
  3421  FTTSWMSGTL EQAQQGKREK LGVQVRPENW CSQMDKGMLH FGSSDISPYA LPWRPEEPAR
  3481  ISWKQYMSGS AVDVSCSQKP QGLTLSNVAR CSSMDNGLED QNSPFHSHLS TYANICDLST
  3541  THSSTENAQG SNEAWEVFRG SSSIALGDPH IPTSPEGVAP TSGHDRRPQF RGPSGEADCL
  3601  RSKPPLAKGS AAGPVDEIML LYPSEAGCPV GQTRTNTFEQ GTQTLGSRRH WSSTDISFAQ
  3661  PEASAVSAFD LASWTSMHNL SLHLSQLLHS TSELLGSLSQ PDVARREQNT KRDIPDKAPQ
  3721  ALMMDGSTQT TVDEGSQTDL TLPTLCLQTS EAEPQGANVI LEGLGSDTST VSQEEGDVPG
  3781  VPQKREAEET AQKMAQLLYL QEESTPYKPQ SPSIPSSHLR FQKAPVGQHL PSVSPSVSDA
  3841  FLPPSSQPEE SYCLVVSSPS PSSPHSPGLF PSTSEYPGDS RVQKKLGPTS ALFVDRASSP
  3901  ILTLSASTQE PGLSPGSLTL SAPSTHPVEG HQKLDSSPDP VDAPRTPMDN YSQTTDELGG
  3961  SQRGRSSLQR SNGRSFLELH SPHSPQQSPK LQFSFLGQHP QQLQPRTTIG VQSRLLPPPL
  4021  RHRSQRLGNS FVPEKVASPE HCPLSGREPS QWQSRTENGG ESSASPGEPQ RTLDRPSSWG
  4081  GLQHLSPCPV SELTDTAGLR GSALGLPQAC QPEELLCFSC QMCMAPEHQH HSLRDLPVHN
  4141  KFSNWCGVQK GSPGGLDMTE EELGASGDLS SEKQEQSPPQ PPNDHSQDSE WSKREQIPLQ
  4201  VGAQNLSLSV ELTEAKLHHG FGEADALLQV LQSGTGEALA ADEPVTSTWK ELYARQKKAI
  4261  ETLRRERAER LGNFCRTRSL SPQKQLSLLP NKDLFIWDLD LPSRRREYLQ QLRKDVVETT
  4321  RSPESVSRSA HTPSDIELML QDYQQAHEEA KVEIARARDQ LRERTEQEKL RIHQKIISQL
  4381  LKEEDKLHTL ANSSSLCTSS NGSLSSGMTS GYNSSPALSG QLQFPENMGH TNLPDSRDVW
  4441  IGDERGGHSA VRKNSAYSHR ASLGSCCCSP SSLSSLGTCF SSSYQDLAKH VVDTSMADVM
  4501  AACSDNLHNL FSCQATAGWN YQGEEQAVQL YYKVFSPTRH GFLGAGVVSQ PLSRVWAAVS
  4561  DPTVWPLYYK PIQTARLHQR VTNSISLVYL VCNTTLCALK QPRDFCCVCV EAKEGHLSVM
  4621  AAQSVYDTSM PRPSRKMVRG EILPSAWILQ PITVEGKEVT RVIYLAQVEL GAPGFPPQLL
  4681  SSFIKRQPLV IARLASFLGR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STARD9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0

Highest tissue expression

12 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.63

gnomAD pLI

0

gnomAD missense Z

2.5

DepMap mean gene effect

-0.21

DepMap dependency class

selective

OntologyGO

Biological processes

• microtubule-based movement
• spindle assembly

Molecular functions

• ATP binding
• lipid binding
• microtubule binding
• microtubule motor activity

Cellular components

• centriole
• cytoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Forkhead-associated (FHA) domain
• Kinesin motor domain
• START domain
• SMAD/FHA domain superfamily
• Kinesin motor domain, conserved site
• START-like domain superfamily
• P-loop containing nucleoside triphosphate hydrolase
• Kinesin motor domain superfamily
• Kinesin motor domain
• FHA domain
• START domain

KeywordsUniProt

• ATP-binding
• Coiled coil
• Cytoplasm
• Cytoskeleton
• Motor protein
• Nucleotide-binding
• Nucleus
• Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of STARD9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ATAD3A