Seroatlas · Human Serome Atlas

KIF21B

Kinesin-like protein KIF21B

Also known as: DKFZP434J212, KI21B_HUMAN, KIAA0449

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75037
Gene: KIF21B
Ensembl: ENSG00000116852
Chromosome: 1
Canonical length: 1637 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Plasma membrane,Mitotic spindle,Mitochondria,Cytosol

OverviewNCBI Gene

This gene encodes a member of the kinesin superfamily. Kinesins are ATP-dependent microtubule-based motor proteins that are involved in the intracellular transport of membranous organelles. Single nucleotide polymorphisms in this gene are associated with inflammatory bowel disease and multiple sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Canonical amino-acid sequenceUniProt

1637 residues, UniProt reviewed canonical sequence.

>O75037|KIF21B
     1  MAGQGDCCVK VAVRIRPQLS KEKIEGCHIC TSVTPGEPQV LLGKDKAFTY DFVFDLDTWQ
    61  EQIYSTCVSK LIEGCFEGYN ATVLAYGQTG AGKTYTMGTG FDMATSEEEQ GIIPRAIAHL
   121  FGGIAERKRR AQEQGVAGPE FKVSAQFLEL YNEEILDLFD STRDPDTRHR RSNIKIHEDA
   181  NGGIYTTGVT SRLIHSQEEL IQCLKQGALS RTTASTQMNV QSSRSHAIFT IHLCQMRMCT
   241  QPDLVNEAVT GLPDGTPPSS EYETLTAKFH FVDLAGSERL KRTGATGERA KEGISINCGL
   301  LALGNVISAL GDQSKKVVHV PYRDSKLTRL LQDSLGGNSQ TIMIACVSPS DRDFMETLNT
   361  LKYANRARNI KNKVVVNQDK TSQQISALRA EIARLQMELM EYKAGKRVIG EDGAEGYSDL
   421  FRENAMLQKE NGALRLRVKA MQEAIDAINN RVTQLMSQEA NLLLAKAGDG NEAIGALIQN
   481  YIREIEELRT KLLESEAMNE SLRRSLSRAS ARSPYSLGAS PAAPAFGGSP ASSMEDASEV
   541  IRRAKQDLER LKKKEVRQRR KSPEKEAFKK RAKLQQENSE ETDENEAEEE EEERDESGCE
   601  EEEGREDEDE DSGSEESLVD SDSDPEEKEV NFQADLADLT CEIEIKQKLI DELENSQRRL
   661  QTLKHQYEEK LILLQNKIRD TQLERDRVLQ NLSTMECYTE EKANKIKADY EKRLREMNRD
   721  LQKLQAAQKE HARLLKNQSR YERELKKLQA EVAEMKKAKV ALMKQMREEQ QRRRLVETKR
   781  NREIAQLKKE QRRQEFQIRA LESQKRQQEM VLRRKTQEVS ALRRLAKPMS ERVAGRAGLK
   841  PPMLDSGAEV SASTTSSEAE SGARSVSSIV RQWNRKINHF LGDHPAPTVN GTRPARKKFQ
   901  KKGASQSFSK AARLKWQSLE RRIIDIVMQR MTIVNLEADM ERLIKKREEL FLLQEALRRK
   961  RERLQAESPE EEKGLQELAE EIEVLAANID YINDGITDCQ ATIVQLEETK EELDSTDTSV
  1021  VISSCSLAEA RLLLDNFLKA SIDKGLQVAQ KEAQIRLLEG RLRQTDMAGS SQNHLLLDAL
  1081  REKAEAHPEL QALIYNVQQE NGYASTDEEI SEFSEGSFSQ SFTMKGSTSH DDFKFKSEPK
  1141  LSAQMKAVSA ECLGPPLDIS TKNITKSLAS LVEIKEDGVG FSVRDPYYRD RVSRTVSLPT
  1201  RGSTFPRQSR ATETSPLTRR KSYDRGQPIR STDVGFTPPS SPPTRPRNDR NVFSRLTSNQ
  1261  SQGSALDKSD DSDSSLSEVL RGIISPVGGA KGARTAPLQC VSMAEGHTKP ILCLDATDEL
  1321  LFTGSKDRSC KMWNLVTGQE IAALKGHPNN VVSIKYCSHS GLVFSVSTSY IKVWDIRDSA
  1381  KCIRTLTSSG QVISGDACAA TSTRAITSAQ GEHQINQIAL SPSGTMLYAA SGNAVRIWEL
  1441  SRFQPVGKLT GHIGPVMCLT VTQTASQHDL VVTGSKDHYV KMFELGECVT GTIGPTHNFE
  1501  PPHYDGIECL AIQGDILFSG SRDNGIKKWD LDQQELIQQI PNAHKDWVCA LAFIPGRPML
  1561  LSACRAGVIK VWNVDNFTPI GEIKGHDSPI NAICTNAKHI FTASSDCRVK LWNYVPGLTP
  1621  CLPRRVLAIK GRATTLP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIF21B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 32 nTPM
retina: 20 nTPM
cerebral cortex: 19 nTPM
amygdala: 17 nTPM
hippocampal formation: 14 nTPM
testis: 13 nTPM

Single-cell type

late spermatids: 157 nCPM
müller glia: 101 nCPM
neutrophils: 86 nCPM
neutrophil progenitors: 77 nCPM
cone photoreceptor cells: 58 nCPM
early spermatids: 47 nCPM

Immune cell

basophil: 6 nTPM
NK-cell: 1.3 nTPM
neutrophil: 1 nTPM
MAIT T-cell: 0.9 nTPM
gdT-cell: 0.8 nTPM
memory CD8 T-cell: 0.8 nTPM

Brain region

cerebral cortex: 65 nTPM
basal ganglia: 54 nTPM
amygdala: 54 nTPM
hippocampal formation: 52 nTPM
hypothalamus: 40 nTPM
white matter: 36 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.43
gnomAD pLI: 0
gnomAD missense Z: 2.96
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

microtubule-based movement

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KIF21B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIF21B as an antibody target. Whether an autoantibody or antibody against KIF21B could matter depends on whether native KIF21B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIF21B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KIF21B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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