Seroatlas · Human Serome Atlas

HRAS

GTPase HRas

Also known as: HRAS1, RASH_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P01112
Gene
HRAS
Ensembl
ENSG00000174775
Chromosome
11
Canonical length
189 aa
Protein class
Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins
Subcellular location
Nucleoplasm,Basal body,Cytosol

OverviewNCBI Gene

This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, cognitive disability, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

189 residues, UniProt reviewed canonical sequence.

>P01112|HRAS
     1  MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET CLLDILDTAG
    61  QEEYSAMRDQ YMRTGEGFLC VFAINNTKSF EDIHQYREQI KRVKDSDDVP MVLVGNKCDL
   121  AARTVESRQA QDLARSYGIP YIETSAKTRQ GVEDAFYTLV REIRQHKLRK LNPPDESGPG
   181  CMSCKCVLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HRAS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
124 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 124 nTPM
  • cerebral cortex: 97 nTPM
  • amygdala: 96 nTPM
  • hippocampal formation: 87 nTPM
  • hypothalamus: 85 nTPM
  • midbrain: 85 nTPM

Single-cell type

  • breast myoepithelial cells: 82 nCPM
  • suprabasal keratinocytes: 78 nCPM
  • basal keratinocytes: 66 nCPM
  • esophageal suprabasal cells: 57 nCPM
  • ocular epithelial cells: 49 nCPM
  • esophageal basal cells: 45 nCPM

Immune cell

  • non-classical monocyte: 4 nTPM
  • naive B-cell: 1.9 nTPM
  • T-reg: 1.5 nTPM
  • plasmacytoid DC: 1 nTPM
  • intermediate monocyte: 0.8 nTPM
  • memory CD4 T-cell: 0.8 nTPM

Brain region

  • pons: 35 nTPM
  • white matter: 34 nTPM
  • cerebral cortex: 33 nTPM
  • midbrain: 32 nTPM
  • basal ganglia: 32 nTPM
  • medulla oblongata: 31 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HRAS.

Disease | AllUniProt

Conditions HRAS is implicated in, by any mechanism.

Disease | GeneticClinVar

52 pathogenic / likely-pathogenic of 728 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.93
gnomAD pLI
0.08
gnomAD missense Z
1.51
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HRAS in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HRAS as an antibody target. Whether an autoantibody or antibody against HRAS could matter depends on whether native HRAS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HRAS is annotated at the cell surface, where native HRAS is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label HRAS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HRAS. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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