Seroatlas · Human Serome Atlas

KIF16B

Kinesin-like protein KIF16B

Also known as: C20orf23, dJ971B4.1, FLJ20135, KI16B_HUMAN, SNX23

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96L93
Gene: KIF16B
Ensembl: ENSG00000089177
Chromosome: 20
Canonical length: 1317 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

The protein encoded by this gene is a kinesin-like protein that may be involved in intracellular trafficking. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

1317 residues, UniProt reviewed canonical sequence.

>Q96L93|KIF16B
     1  MASVKVAVRV RPMNRREKDL EAKFIIQMEK SKTTITNLKI PEGGTGDSGR ERTKTFTYDF
    61  SFYSADTKSP DYVSQEMVFK TLGTDVVKSA FEGYNACVFA YGQTGSGKSY TMMGNSGDSG
   121  LIPRICEGLF SRINETTRWD EASFRTEVSY LEIYNERVRD LLRRKSSKTF NLRVREHPKE
   181  GPYVEDLSKH LVQNYGDVEE LMDAGNINRT TAATGMNDVS SRSHAIFTIK FTQAKFDSEM
   241  PCETVSKIHL VDLAGSERAD ATGATGVRLK EGGNINKSLV TLGNVISALA DLSQDAANTL
   301  AKKKQVFVPY RDSVLTWLLK DSLGGNSKTI MIATISPADV NYGETLSTLR YANRAKNIIN
   361  KPTINEDANV KLIRELRAEI ARLKTLLAQG NQIALLDSPT ALSMEEKLQQ NEARVQELTK
   421  EWTNKWNETQ NILKEQTLAL RKEGIGVVLD SELPHLIGID DDLLSTGIIL YHLKEGQTYV
   481  GRDDASTEQD IVLHGLDLES EHCIFENIGG TVTLIPLSGS QCSVNGVQIV EATHLNQGAV
   541  ILLGRTNMFR FNHPKEAAKL REKRKSGLLS SFSLSMTDLS KSRENLSAVM LYNPGLEFER
   601  QQREELEKLE SKRKLIEEME EKQKSDKAEL ERMQQEVETQ RKETEIVQLQ IRKQEESLKR
   661  RSFHIENKLK DLLAEKEKFE EERLREQQEI ELQKKRQEEE TFLRVQEELQ RLKELNNNEK
   721  AEKFQIFQEL DQLQKEKDEQ YAKLELEKKR LEEQEKEQVM LVAHLEEQLR EKQEMIQLLR
   781  RGEVQWVEEE KRDLEGIRES LLRVKEARAG GDEDGEELEK AQLRFFEFKR RQLVKLVNLE
   841  KDLVQQKDIL KKEVQEEQEI LECLKCEHDK ESRLLEKHDE SVTDVTEVPQ DFEKIKPVEY
   901  RLQYKERQLQ YLLQNHLPTL LEEKQRAFEI LDRGPLSLDN TLYQVEKEME EKEEQLAQYQ
   961  ANANQLQKLQ ATFEFTANIA RQEEKVRKKE KEILESREKQ QREALERALA RLERRHSALQ
  1021  RHSTLGMEIE EQRQKLASLN SGSREQSGLQ ASLEAEQEAL EKDQERLEYE IQQLKQKIYE
  1081  VDGVQKDHHG TLEGKVASSS LPVSAEKSHL VPLMDARINA YIEEEVQRRL QDLHRVISEG
  1141  CSTSADTMKD NEKLHNGTIQ RKLKYERMVS RSLGANPDDL KDPIKISIPR YVLCGQGKDA
  1201  HFEFEVKITV LDETWTVFRR YSRFREMHKT LKLKYAELAA LEFPPKKLFG NKDERVIAER
  1261  RSHLEKYLRD FFSVMLQSAT SPLHINKVGL TLSKHTICEF SPFFKKGVFD YSSHGTG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIF16B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 28 nTPM
adrenal gland: 24 nTPM
colon: 16 nTPM
skeletal muscle: 16 nTPM
small intestine: 14 nTPM
breast: 13 nTPM

Single-cell type

adrenal cortex cells: 426 nCPM
retinal horizontal cells: 283 nCPM
renal collecting duct intercalated cells: 233 nCPM
pituitary stem cells: 227 nCPM
thyrotrophs: 218 nCPM
urothelial cells: 185 nCPM

Immune cell

NK-cell: 4.5 nTPM
myeloid DC: 3.4 nTPM
MAIT T-cell: 2.7 nTPM
memory B-cell: 2.7 nTPM
naive B-cell: 2.5 nTPM
naive CD4 T-cell: 2.3 nTPM

Brain region

cerebral cortex: 28 nTPM
white matter: 24 nTPM
hypothalamus: 22 nTPM
medulla oblongata: 22 nTPM
thalamus: 21 nTPM
basal ganglia: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.83
gnomAD pLI: 0
gnomAD missense Z: 1.1
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KIF16B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIF16B as an antibody target. Whether an autoantibody or antibody against KIF16B could matter depends on whether native KIF16B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIF16B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KIF16B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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