Seroatlas · Human Serome Atlas

GNA12

Guanine nucleotide-binding protein subunit alpha-12

Also known as: gep, GNA12_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q03113
Gene
GNA12
Ensembl
ENSG00000146535
Chromosome
7
Canonical length
381 aa
Protein class
Human disease related genes, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

Enables G protein activity; protein phosphatase 2A binding activity; and protein phosphatase activator activity. Involved in Rho-activating G protein-coupled receptor signaling pathway; regulation of TOR signaling; and regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in lateral plasma membrane; neuron projection; and neuronal cell body. Is active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

381 residues, UniProt reviewed canonical sequence.

>Q03113|GNA12
     1  MSGVVRTLSR CLLPAEAGGA RERRAGSGAR DAEREARRRS RDIDALLARE RRAVRRLVKI
    61  LLLGAGESGK STFLKQMRII HGREFDQKAL LEFRDTIFDN ILKGSRVLVD ARDKLGIPWQ
   121  YSENEKHGMF LMAFENKAGL PVEPATFQLY VPALSALWRD SGIREAFSRR SEFQLGESVK
   181  YFLDNLDRIG QLNYFPSKQD ILLARKATKG IVEHDFVIKK IPFKMVDVGG QRSQRQKWFQ
   241  CFDGITSILF MVSSSEYDQV LMEDRRTNRL VESMNIFETI VNNKLFFNVS IILFLNKMDL
   301  LVEKVKTVSI KKHFPDFRGD PHRLEDVQRY LVQCFDRKRR NRSKPLFHHF TTAIDTENVR
   361  FVFHAVKDTI LQENLKDIML Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GNA12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
35 nTPM

Expression across tissuesHPA

Tissue

  • midbrain: 35 nTPM
  • amygdala: 35 nTPM
  • basal ganglia: 30 nTPM
  • spinal cord: 30 nTPM
  • cerebral cortex: 28 nTPM
  • hypothalamus: 25 nTPM

Single-cell type

  • syncytiotrophoblasts: 699 nCPM
  • somatotrophs: 340 nCPM
  • cytotrophoblasts: 309 nCPM
  • cdc: 279 nCPM
  • b-cells: 228 nCPM
  • monocytes: 183 nCPM

Immune cell

  • naive B-cell: 1.8 nTPM
  • plasmacytoid DC: 1.8 nTPM
  • basophil: 1.5 nTPM
  • intermediate monocyte: 1.3 nTPM
  • memory B-cell: 1 nTPM
  • T-reg: 0.7 nTPM

Brain region

  • medulla oblongata: 99 nTPM
  • thalamus: 98 nTPM
  • spinal cord: 84 nTPM
  • basal ganglia: 84 nTPM
  • midbrain: 77 nTPM
  • amygdala: 75 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.28
gnomAD pLI
0.97
gnomAD missense Z
2.09
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GNA12 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GNA12 as an antibody target. Whether an autoantibody or antibody against GNA12 could matter depends on whether native GNA12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GNA12 is annotated at the cell surface, where native GNA12 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GNA12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GNA12. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...