KIF20B

Protein identityUniProt · HPA

UniProt accession

Q96Q89

Gene

KIF20B

Ensembl

ENSG00000138182

Chromosome

10

Canonical length

1820 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Cytokinetic bridge,Midbody,Centrosome,Basal body,Cytosol,Perinuclear theca

OverviewNCBI Gene

Enables several functions, including ATP hydrolysis activity; WW domain binding activity; and plus-end-directed microtubule motor activity. Involved in positive regulation of cell population proliferation and positive regulation of cytokinesis. Located in several cellular components, including microtubule cytoskeleton; midbody; and nuclear lumen. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1820 residues, UniProt reviewed canonical sequence.

>Q96Q89|KIF20B
     1  MESNFNQEGV PRPSYVFSAD PIARPSEINF DGIKLDLSHE FSLVAPNTEA NSFESKDYLQ
    61  VCLRIRPFTQ SEKELESEGC VHILDSQTVV LKEPQCILGR LSEKSSGQMA QKFSFSKVFG
   121  PATTQKEFFQ GCIMQPVKDL LKGQSRLIFT YGLTNSGKTY TFQGTEENIG ILPRTLNVLF
   181  DSLQERLYTK MNLKPHRSRE YLRLSSEQEK EEIASKSALL RQIKEVTVHN DSDDTLYGSL
   241  TNSLNISEFE ESIKDYEQAN LNMANSIKFS VWVSFFEIYN EYIYDLFVPV SSKFQKRKML
   301  RLSQDVKGYS FIKDLQWIQV SDSKEAYRLL KLGIKHQSVA FTKLNNASSR SHSIFTVKIL
   361  QIEDSEMSRV IRVSELSLCD LAGSERTMKT QNEGERLRET GNINTSLLTL GKCINVLKNS
   421  EKSKFQQHVP FRESKLTHYF QSFFNGKGKI CMIVNISQCY LAYDETLNVL KFSAIAQKVC
   481  VPDTLNSSQE KLFGPVKSSQ DVSLDSNSNS KILNVKRATI SWENSLEDLM EDEDLVEELE
   541  NAEETQNVET KLLDEDLDKT LEENKAFISH EEKRKLLDLI EDLKKKLINE KKEKLTLEFK
   601  IREEVTQEFT QYWAQREADF KETLLQEREI LEENAERRLA IFKDLVGKCD TREEAAKDIC
   661  ATKVETEETH NYVGFEDIID SLQDNVADIK KQAEIAHLYI ASLPDPQEAT ACLELKFNQI
   721  KAELAKTKGE LIKTKEELKK RENESDSLIQ ELETSNKKII TQNQRIKELI NIIDQKEDTI
   781  NEFQNLKSHM ENTFKCNDKA DTSSLIINNK LICNETVEVP KDSKSKICSE RKRVNENELQ
   841  QDEPPAKKGS IHVSSAITED QKKSEEVRPN IAEIEDIRVL QENNEGLRAF LLTIENELKN
   901  EKEEKAELNK QIVHFQQELS LSEKKNLTLS KEVQQIQSNY DIAIAELHVQ KSKNQEQEEK
   961  IMKLSNEIET ATRSITNNVS QIKLMHTKID ELRTLDSVSQ ISNIDLLNLR DLSNGSEEDN
  1021  LPNTQLDLLG NDYLVSKQVK EYRIQEPNRE NSFHSSIEAI WEECKEIVKA SSKKSHQIEE
  1081  LEQQIEKLQA EVKGYKDENN RLKEKEHKNQ DDLLKEKETL IQQLKEELQE KNVTLDVQIQ
  1141  HVVEGKRALS ELTQGVTCYK AKIKELETIL ETQKVECSHS AKLEQDILEK ESIILKLERN
  1201  LKEFQEHLQD SVKNTKDLNV KELKLKEEIT QLTNNLQDMK HLLQLKEEEE ETNRQETEKL
  1261  KEELSASSAR TQNLKADLQR KEEDYADLKE KLTDAKKQIK QVQKEVSVMR DEDKLLRIKI
  1321  NELEKKKNQC SQELDMKQRT IQQLKEQLNN QKVEEAIQQY ERACKDLNVK EKIIEDMRMT
  1381  LEEQEQTQVE QDQVLEAKLE EVERLATELE KWKEKCNDLE TKNNQRSNKE HENNTDVLGK
  1441  LTNLQDELQE SEQKYNADRK KWLEEKMMLI TQAKEAENIR NKEMKKYAED RERFFKQQNE
  1501  MEILTAQLTE KDSDLQKWRE ERDQLVAALE IQLKALISSN VQKDNEIEQL KRIISETSKI
  1561  ETQIMDIKPK RISSADPDKL QTEPLSTSFE ISRNKIEDGS VVLDSCEVST ENDQSTRFPK
  1621  PELEIQFTPL QPNKMAVKHP GCTTPVTVKI PKARKRKSNE MEEDLVKCEN KKNATPRTNL
  1681  KFPISDDRNS SVKKEQKVAI RPSSKKTYSL RSQASIIGVN LATKKKEGTL QKFGDFLQHS
  1741  PSILQSKAKK IIETMSSSKL SNVEASKENV SQPKRAKRKL YTSEISSPID ISGQVILMDQ
  1801  KMKESDHQII KRRLRTKTAK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIF20B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.49

Highest tissue expression

9.6 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KIF20B.

Disease | ImmuneIEDB

Conditions an epitope on KIF20B was assayed in.

• bladder urothelial carcinoma T cell
• esophageal cancer T cell
• cholangiocarcinoma T cell
• colorectal cancer T cell
• lung cancer T cell
• urinary bladder cancer T cell

ReferencesPubMed · IEDB

Publications for KIF20B from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.69

gnomAD pLI

0

gnomAD missense Z

-0.6

DepMap mean gene effect

-0.07

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell division
• microtubule-based movement
• neural tube closure
• neuron projection morphogenesis
• positive regulation of cell population proliferation
• positive regulation of cytokinesis
• positive regulation of intracellular protein transport
• positive regulation of mitotic cytokinetic process
• positive regulation of neuron migration
• protein localization to microtubule
• regulation of cell cycle
• regulation of establishment of cell polarity
• regulation of mitotic nuclear division

Molecular functions

• ATP binding
• ATP hydrolysis activity
• microtubule binding
• microtubule motor activity
• plus-end-directed microtubule motor activity
• protein homodimerization activity
• WW domain binding

Cellular components

• centrosome
• ciliary basal body
• contractile ring
• cytoplasm
• cytosol
• growth cone
• intercellular bridge
• kinesin complex
• microtubule
• midbody
• mitotic spindle midzone
• mitotic spindle pole
• nucleolus
• nucleoplasm
• nucleus
• perinuclear region of cytoplasm
• perinuclear theca
• spindle midzone

Protein domainsUniProt · Pfam · InterPro

• Kinesin motor domain
• Kinesin motor domain, conserved site
• P-loop containing nucleoside triphosphate hydrolase
• Kinesin motor domain superfamily
• Kinesin-like protein KIF11-like
• Kinesin motor domain

KeywordsUniProt

• ATP-binding
• Cell cycle
• Cell division
• Cell projection
• Coiled coil
• Cytoplasm
• Cytoskeleton
• Microtubule
• Mitosis
• Motor protein
• Nucleotide-binding
• Nucleus
• Oncogene
• Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of KIF20B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PRC1
• SHTN1
• PIN1