RAB38

Protein identityUniProt · HPA

UniProt accession

P57729

Gene

RAB38

Ensembl

ENSG00000123892

Chromosome

11

Canonical length

211 aa

Protein class

Predicted intracellular proteins

OverviewNCBI Gene

Enables several functions, including AP-1 adaptor complex binding activity; AP-3 adaptor complex binding activity; and BLOC-2 complex binding activity. Involved in several processes, including endosome to melanosome transport; melanosome assembly; and phagosome acidification. Located in several cellular components, including cytoplasmic vesicle; lysosome; and mitochondria-associated endoplasmic reticulum membrane contact site. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

211 residues, UniProt reviewed canonical sequence.

>P57729|RAB38
     1  MQAPHKEHLY KLLVIGDLGV GKTSIIKRYV HQNFSSHYRA TIGVDFALKV LHWDPETVVR
    61  LQLWDIAGQE RFGNMTRVYY REAMGAFIVF DVTRPATFEA VAKWKNDLDS KLSLPNGKPV
   121  SVVLLANKCD QGKDVLMNNG LKMDQFCKEH GFVGWFETSA KENINIDEAS RCLVKHILAN
   181  ECDLMESIEP DVVKPHLTST KVASCSGCAK S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB38 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.33

Highest tissue expression

48 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RAB38.

Disease | ImmuneIEDB

Conditions an epitope on RAB38 was assayed in.

• melanoma T cell
• skin melanoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.36

gnomAD pLI

0

gnomAD missense Z

-0.16

DepMap mean gene effect

0.08

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• endosome to melanosome transport
• intracellular protein transport
• melanosome assembly
• melanosome organization
• mitochondrion organization
• phagosome acidification
• platelet dense granule organization
• positive regulation of melanin biosynthetic process
• positive regulation of phosphatidylcholine biosynthetic process
• positive regulation of protein localization to cell periphery
• protein localization to membrane
• protein transport
• small GTPase-mediated signal transduction
• vesicle-mediated transport

Molecular functions

• AP-1 adaptor complex binding
• AP-3 adaptor complex binding
• BLOC-2 complex binding
• G protein activity
• GTP binding
• GTP-dependent protein binding
• GTPase activity
• metal ion binding

Cellular components

• cell body
• cytosol
• early endosome
• endomembrane system
• lysosome
• melanosome
• melanosome membrane
• membrane
• mitochondria-associated endoplasmic reticulum membrane contact site
• mitochondrion
• perinuclear region of cytoplasm
• phagocytic vesicle
• phagocytic vesicle membrane
• plasma membrane
• trans-Golgi network

Protein domainsUniProt · Pfam · InterPro

• Small GTPase
• Small GTP-binding domain
• P-loop containing nucleoside triphosphate hydrolase
• Ras-related protein Rab29/Rab38/Rab32
• Ras family

KeywordsUniProt

• Cell membrane
• Cytoplasmic vesicle
• GTP-binding
• Hydrolase
• Lipoprotein
• Magnesium
• Membrane
• Metal-binding
• Nucleotide-binding
• Palmitate
• Prenylation
• Protein transport
• Transport

InteractionsUniProt · HPA

Protein binding partners of RAB38 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ANKRD27