Seroatlas · Human Serome Atlas

CRACR2A

EF-hand calcium-binding domain-containing protein 4B

Also known as: EFC4B_HUMAN, EFCAB4B, MGC4266, RAB46

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BSW2
Gene
CRACR2A
Ensembl
ENSG00000130038
Chromosome
12
Canonical length
731 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Enables GTPase activity and calcium ion binding activity. Involved in several processes, including activation of store-operated calcium channel activity; positive regulation of JNK cascade; and store-operated calcium entry. Located in several cellular components, including Golgi apparatus; Weibel-Palade body; and immunological synapse. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

731 residues, UniProt reviewed canonical sequence.

>Q9BSW2|CRACR2A
     1  MAAPDGRVVS RPQRLGQGSG QGPKGSGACL HPLDSLEQKE TQEQTSGQLV MLRKAQEFFQ
    61  TCDAEGKGFI ARKDMQRLHK ELPLSLEELE DVFDALDADG NGYLTPQEFT TGFSHFFFSQ
   121  NNPSQEDAGE QVAQRHEEKV YLSRGDEDLG DMGEDEEAQF RMLMDRLGAQ KVLEDESDVK
   181  QLWLQLKKEE PHLLSNFEDF LTRIISQLQE AHEEKNELEC ALKRKIAAYD EEIQHLYEEM
   241  EQQIKSEKEQ FLLKDTERFQ ARSQELEQKL LCKEQELEQL TQKQKRLEGQ CTALHHDKHE
   301  TKAENTKLKL TNQELARELE RTSWELQDAQ QQLESLQQEA CKLHQEKEME VYRVTESLQR
   361  EKAGLLKQLD FLRERNKHLR DERDICFQKN KAAKANTAAS RASWKKRSGS VIGKYVDSRG
   421  ILRSQSEEEE EVFGIPRRSS LGLSGYPLTE EEPGTGEPGP GGPYPRPLRR IISVEEDPLP
   481  QLLDGGFEQP LSKCSEEEEV SDQGVQGQIP EAPPLKLTPT SPRGQPVGKE ALCKEESSPS
   541  APDRLFKIVF VGNSAVGKTS FLRRFCEDRF SPGMAATVGI DYRVKTLNVD NSQVALQLWD
   601  TAGQERYRCI TQQFFRKADG VIVMYDLTDK QSFLSVRRWL SSVEEAVGDR VPVLLLGNKL
   661  DNEKEREVPR GLGEQLATEN NLIFYECSAY SGHNTKESLL HLARFLKEQE DTVREDTIQV
   721  GHPAKKKSCC G

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CRACR2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
36 nTPM

Expression across tissuesHPA

Tissue

  • salivary gland: 36 nTPM
  • bone marrow: 16 nTPM
  • rectum: 13 nTPM
  • colon: 8.6 nTPM
  • small intestine: 7.9 nTPM
  • thymus: 5.6 nTPM

Single-cell type

  • salivary ionocytes: 383 nCPM
  • salivary acinar cells: 277 nCPM
  • goblet cells: 234 nCPM
  • lacrimal acinar cells: 198 nCPM
  • conjunctival goblet cells: 129 nCPM
  • salivary duct cells: 115 nCPM

Immune cell

  • basophil: 17 nTPM
  • gdT-cell: 5 nTPM
  • MAIT T-cell: 5 nTPM
  • memory CD8 T-cell: 4 nTPM
  • NK-cell: 3.5 nTPM
  • memory B-cell: 2.7 nTPM

Brain region

  • basal ganglia: 2.9 nTPM
  • choroid plexus: 2.3 nTPM
  • medulla oblongata: 2.3 nTPM
  • thalamus: 2.3 nTPM
  • pons: 1.7 nTPM
  • white matter: 1.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.87
gnomAD pLI
0
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CRACR2A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CRACR2A as an antibody target. Whether an autoantibody or antibody against CRACR2A could matter depends on whether native CRACR2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CRACR2A is annotated at the cell surface, where native CRACR2A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CRACR2A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CRACR2A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...