Seroatlas · Human Serome Atlas

RAC1

Ras-related C3 botulinum toxin substrate 1

Also known as: p21-Rac1, Rac-1, RAC1_HUMAN, TC-25

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P63000
Gene
RAC1
Ensembl
ENSG00000136238
Chromosome
7
Canonical length
192 aa
Protein class
Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins
Subcellular location
Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Canonical amino-acid sequenceUniProt

192 residues, UniProt reviewed canonical sequence.

>P63000|RAC1
     1  MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDGKP VNLGLWDTAG
    61  QEDYDRLRPL SYPQTDVFLI CFSLVSPASF ENVRAKWYPE VRHHCPNTPI ILVGTKLDLR
   121  DDKDTIEKLK EKKLTPITYP QGLAMAKEIG AVKYLECSAL TQRGLKTVFD EAIRAVLCPP
   181  PVKKRKRKCL LL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
304 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 304 nTPM
  • esophagus: 304 nTPM
  • midbrain: 251 nTPM
  • hippocampal formation: 222 nTPM
  • amygdala: 209 nTPM
  • basal ganglia: 198 nTPM

Single-cell type

  • esophageal apical cells: 6,772 nCPM
  • esophageal suprabasal cells: 2,040 nCPM
  • gastric progenitor cells: 1,778 nCPM
  • extravillous trophoblasts: 1,387 nCPM
  • oocytes: 1,207 nCPM
  • kupffer cells: 1,045 nCPM

Immune cell

  • neutrophil: 176 nTPM
  • classical monocyte: 123 nTPM
  • myeloid DC: 120 nTPM
  • non-classical monocyte: 89 nTPM
  • intermediate monocyte: 88 nTPM
  • eosinophil: 67 nTPM

Brain region

  • white matter: 232 nTPM
  • spinal cord: 231 nTPM
  • medulla oblongata: 212 nTPM
  • basal ganglia: 202 nTPM
  • cerebral cortex: 195 nTPM
  • midbrain: 193 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RAC1.

Disease | AllUniProt

Conditions RAC1 is implicated in, by any mechanism.

  • Intellectual developmental disorder, autosomal dominant 48 (MRD48) MIM:617751

Disease | GeneticClinVar

27 pathogenic / likely-pathogenic of 107 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.47
gnomAD pLI
0.76
gnomAD missense Z
3.13
DepMap mean gene effect
-0.76
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAC1 as an antibody target. Whether an autoantibody or antibody against RAC1 could matter depends on whether native RAC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAC1 is annotated at the cell surface, where native RAC1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RAC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RAC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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