Seroatlas · Human Serome Atlas

GBP5

Guanylate-binding protein 5

Also known as: GBP5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96PP8
Gene
GBP5
Ensembl
ENSG00000154451
Chromosome
1
Canonical length
586 aa
Protein class
Predicted intracellular proteins
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene belongs to the TRAFAC class dynamin-like GTPase superfamily. The encoded protein acts as an activator of NLRP3 inflammasome assembly and has a role in innate immunity and inflammation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2017]

Canonical amino-acid sequenceUniProt

586 residues, UniProt reviewed canonical sequence.

>Q96PP8|GBP5
     1  MALEIHMSDP MCLIENFNEQ LKVNQEALEI LSAITQPVVV VAIVGLYRTG KSYLMNKLAG
    61  KNKGFSVAST VQSHTKGIWI WCVPHPNWPN HTLVLLDTEG LGDVEKADNK NDIQIFALAL
   121  LLSSTFVYNT VNKIDQGAID LLHNVTELTD LLKARNSPDL DRVEDPADSA SFFPDLVWTL
   181  RDFCLGLEID GQLVTPDEYL ENSLRPKQGS DQRVQNFNLP RLCIQKFFPK KKCFIFDLPA
   241  HQKKLAQLET LPDDELEPEF VQQVTEFCSY IFSHSMTKTL PGGIMVNGSR LKNLVLTYVN
   301  AISSGDLPCI ENAVLALAQR ENSAAVQKAI AHYDQQMGQK VQLPMETLQE LLDLHRTSER
   361  EAIEVFMKNS FKDVDQSFQK ELETLLDAKQ NDICKRNLEA SSDYCSALLK DIFGPLEEAV
   421  KQGIYSKPGG HNLFIQKTEE LKAKYYREPR KGIQAEEVLQ KYLKSKESVS HAILQTDQAL
   481  TETEKKKKEA QVKAEAEKAE AQRLAAIQRQ NEQMMQERER LHQEQVRQME IAKQNWLAEQ
   541  QKMQEQQMQE QAAQLSTTFQ AQNRSLLSEL QHAQRTVNND DPCVLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GBP5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
41 nTPM

Expression across tissuesHPA

Tissue

  • appendix: 41 nTPM
  • lymph node: 27 nTPM
  • spleen: 24 nTPM
  • bone marrow: 17 nTPM
  • tonsil: 12 nTPM
  • lung: 9.9 nTPM

Single-cell type

  • nk-cells: 97 nCPM
  • t-cells: 78 nCPM
  • kupffer cells: 45 nCPM
  • neutrophils: 42 nCPM
  • innate lymphoid cells: 40 nCPM
  • monocytes: 25 nCPM

Immune cell

  • T-reg: 98 nTPM
  • MAIT T-cell: 64 nTPM
  • neutrophil: 46 nTPM
  • gdT-cell: 42 nTPM
  • memory CD8 T-cell: 38 nTPM
  • memory CD4 T-cell: 27 nTPM

Brain region

  • medulla oblongata: 6.7 nTPM
  • choroid plexus: 6.2 nTPM
  • cerebral cortex: 5.3 nTPM
  • pons: 4.9 nTPM
  • cerebellum: 4.7 nTPM
  • thalamus: 4.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.03
gnomAD pLI
0
gnomAD missense Z
-0.3
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GBP5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GBP5 as an antibody target. Whether an autoantibody or antibody against GBP5 could matter depends on whether native GBP5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GBP5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GBP5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GBP5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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