Seroatlas · Human Serome Atlas

MYO1C

Unconventional myosin-Ic

Also known as: MYO1C_HUMAN, MyoIC, myr2, NMI

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O00159
Gene
MYO1C
Ensembl
ENSG00000197879
Chromosome
17
Canonical length
1063 aa
Protein class
Predicted intracellular proteins, Transporters
Subcellular location
Nuclear bodies,Plasma membrane

OverviewNCBI Gene

This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. The mouse ortholog of this protein also functions in intracellular vesicle transport to the plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. The related gene myosin IE has been referred to as myosin IC in the literature, but it is a distinct locus on chromosome 19. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1063 residues, UniProt reviewed canonical sequence.

>O00159|MYO1C
     1  MALQVELVPT GEIIRVVHPH RPCKLALGSD GVRVTMESAL TARDRVGVQD FVLLENFTSE
    61  AAFIENLRRR FRENLIYTYI GPVLVSVNPY RDLQIYSRQH MERYRGVSFY EVPPHLFAVA
   121  DTVYRALRTE RRDQAVMISG ESGAGKTEAT KRLLQFYAET CPAPERGGAV RDRLLQSNPV
   181  LEAFGNAKTL RNDNSSRFGK YMDVQFDFKG APVGGHILSY LLEKSRVVHQ NHGERNFHIF
   241  YQLLEGGEEE TLRRLGLERN PQSYLYLVKG QCAKVSSIND KSDWKVVRKA LTVIDFTEDE
   301  VEDLLSIVAS VLHLGNIHFA ANEESNAQVT TENQLKYLTR LLSVEGSTLR EALTHRKIIA
   361  KGEELLSPLN LEQAAYARDA LAKAVYSRTF TWLVGKINRS LASKDVESPS WRSTTVLGLL
   421  DIYGFEVFQH NSFEQFCINY CNEKLQQLFI ELTLKSEQEE YEAEGIAWEP VQYFNNKIIC
   481  DLVEEKFKGI ISILDEECLR PGEATDLTFL EKLEDTVKHH PHFLTHKLAD QRTRKSLGRG
   541  EFRLLHYAGE VTYSVTGFLD KNNDLLFRNL KETMCSSKNP IMSQCFDRSE LSDKKRPETV
   601  ATQFKMSLLQ LVEILQSKEP AYVRCIKPND AKQPGRFDEV LIRHQVKYLG LLENLRVRRA
   661  GFAYRRKYEA FLQRYKSLCP ETWPTWAGRP QDGVAVLVRH LGYKPEEYKM GRTKIFIRFP
   721  KTLFATEDAL EVRRQSLATK IQAAWRGFHW RQKFLRVKRS AICIQSWWRG TLGRRKAAKR
   781  KWAAQTIRRL IRGFVLRHAP RCPENAFFLD HVRTSFLLNL RRQLPQNVLD TSWPTPPPAL
   841  REASELLREL CIKNMVWKYC RSISPEWKQQ LQQKAVASEI FKGKKDNYPQ SVPRLFISTR
   901  LGTDEISPRV LQALGSEPIQ YAVPVVKYDR KGYKPRSRQL LLTPNAVVIV EDAKVKQRID
   961  YANLTGISVS SLSDSLFVLH VQRADNKQKG DVVLQSDHVI ETLTKTALSA NRVNSININQ
  1021  GSITFAGGPG RDGTIDFTPG SELLITKAKN GHLAVVAPRL NSR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MYO1C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
159 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 159 nTPM
  • blood vessel: 144 nTPM
  • breast: 115 nTPM
  • colon: 101 nTPM
  • heart muscle: 94 nTPM
  • endometrium: 93 nTPM

Single-cell type

  • alveolar cells type 1: 295 nCPM
  • adipocytes: 194 nCPM
  • colonocytes: 146 nCPM
  • goblet cells: 139 nCPM
  • vascular smooth muscle cells: 138 nCPM
  • retinal pigment epithelial cells: 115 nCPM

Immune cell

  • memory B-cell: 4.8 nTPM
  • naive B-cell: 3.8 nTPM
  • memory CD4 T-cell: 2.1 nTPM
  • intermediate monocyte: 2 nTPM
  • T-reg: 1.9 nTPM
  • non-classical monocyte: 1.7 nTPM

Brain region

  • choroid plexus: 31 nTPM
  • hypothalamus: 26 nTPM
  • pons: 26 nTPM
  • thalamus: 24 nTPM
  • medulla oblongata: 23 nTPM
  • cerebellum: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.68
gnomAD pLI
0
gnomAD missense Z
-0.64
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MYO1C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MYO1C as an antibody target. Whether an autoantibody or antibody against MYO1C could matter depends on whether native MYO1C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MYO1C is annotated at the cell surface, where native MYO1C is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MYO1C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MYO1C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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