Seroatlas · Human Serome Atlas

HS6ST1

Heparan-sulfate 6-O-sulfotransferase 1

Also known as: H6ST1_HUMAN, HS6ST

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O60243
Gene
HS6ST1
Ensembl
ENSG00000136720
Chromosome
2
Canonical length
411 aa
Protein class
Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biological activities. This enzyme is a type II integral membrane protein and is responsible for 6-O-sulfation of heparan sulfate. This enzyme does not share significant sequence similarity with other known sulfotransferases. A pseudogene located on chromosome 1 has been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

411 residues, UniProt reviewed canonical sequence.

>O60243|HS6ST1
     1  MRRRRAGGRT MVERASKFVL VVAGSVCFML ILYQYAGPGL SLGAPGGRAP PDDLDLFPTP
    61  DPHYEKKYYF PVRELERSLR FDMKGDDVIV FLHIQKTGGT TFGRHLVQNV RLEVPCDCRP
   121  GQKKCTCYRP NRRETWLFSR FSTGWSCGLH ADWTELTNCV PGVLDRRDSA ALRTPRKFYY
   181  ITLLRDPVSR YLSEWRHVQR GATWKTSLHM CDGRTPTPEE LPPCYEGTDW SGCTLQEFMD
   241  CPYNLANNRQ VRMLADLSLV GCYNLSFIPE GKRAQLLLES AKKNLRGMAF FGLTEFQRKT
   301  QYLFERTFNL KFIRPFMQYN STRAGGVEVD EDTIRRIEEL NDLDMQLYDY AKDLFQQRYQ
   361  YKRQLERREQ RLRSREERLL HRAKEALPRE DADEPGRVPT EDYMSHIIEK W

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HS6ST1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
64 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 64 nTPM
  • cerebral cortex: 64 nTPM
  • adrenal gland: 56 nTPM
  • liver: 41 nTPM
  • skeletal muscle: 32 nTPM
  • amygdala: 32 nTPM

Single-cell type

  • renal collecting duct principal cells: 242 nCPM
  • mast cells: 213 nCPM
  • cone photoreceptor cells: 159 nCPM
  • salivary basal cells: 120 nCPM
  • renal connecting tubule cells: 103 nCPM
  • rod photoreceptor cells: 100 nCPM

Immune cell

  • basophil: 3.1 nTPM
  • plasmacytoid DC: 2.3 nTPM
  • non-classical monocyte: 1.5 nTPM
  • gdT-cell: 1 nTPM
  • classical monocyte: 0.7 nTPM
  • memory B-cell: 0.7 nTPM

Brain region

  • cerebral cortex: 95 nTPM
  • thalamus: 87 nTPM
  • amygdala: 77 nTPM
  • midbrain: 76 nTPM
  • pons: 71 nTPM
  • medulla oblongata: 69 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HS6ST1.

Disease | AllUniProt

Conditions HS6ST1 is implicated in, by any mechanism.

  • Hypogonadotropic hypogonadism 15 with or without anosmia (HH15) MIM:614880

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.38
gnomAD pLI
0.92
gnomAD missense Z
1.92
DepMap mean gene effect
-0.43
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HS6ST1 as an antibody target. Whether an autoantibody or antibody against HS6ST1 could matter depends on whether native HS6ST1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HS6ST1 is annotated at the cell surface, where native HS6ST1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label HS6ST1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HS6ST1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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