Seroatlas · Human Serome Atlas

MX2

Interferon-induced GTP-binding protein Mx2

Also known as: MX2_HUMAN, MXB

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P20592
Gene
MX2
Ensembl
ENSG00000183486
Chromosome
21
Canonical length
715 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Transporters

OverviewNCBI Gene

The protein encoded by this gene has a nuclear and a cytoplasmic form and is a member of both the dynamin family and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope. A nuclear localization signal (NLS) is present at the amino terminal end of the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon. This protein is upregulated by interferon-alpha but does not contain the antiviral activity of a similar myxovirus resistance protein 1. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

715 residues, UniProt reviewed canonical sequence.

>P20592|MX2
     1  MSKAHKPWPY RRRSQFSSRK YLKKEMNSFQ QQPPPFGTVP PQMMFPPNWQ GAEKDAAFLA
    61  KDFNFLTLNN QPPPGNRSQP RAMGPENNLY SQYEQKVRPC IDLIDSLRAL GVEQDLALPA
   121  IAVIGDQSSG KSSVLEALSG VALPRGSGIV TRCPLVLKLK KQPCEAWAGR ISYRNTELEL
   181  QDPGQVEKEI HKAQNVMAGN GRGISHELIS LEITSPEVPD LTIIDLPGIT RVAVDNQPRD
   241  IGLQIKALIK KYIQRQQTIN LVVVPCNVDI ATTEALSMAH EVDPEGDRTI GILTKPDLMD
   301  RGTEKSVMNV VRNLTYPLKK GYMIVKCRGQ QEITNRLSLA EATKKEITFF QTHPYFRVLL
   361  EEGSATVPRL AERLTTELIM HIQKSLPLLE GQIRESHQKA TEELRRCGAD IPSQEADKMF
   421  FLIEKIKMFN QDIEKLVEGE EVVRENETRL YNKIREDFKN WVGILATNTQ KVKNIIHEEV
   481  EKYEKQYRGK ELLGFVNYKT FEIIVHQYIQ QLVEPALSML QKAMEIIQQA FINVAKKHFG
   541  EFFNLNQTVQ STIEDIKVKH TAKAENMIQL QFRMEQMVFC QDQIYSVVLK KVREEIFNPL
   601  GTPSQNMKLN SHFPSNESSV SSFTEIGIHL NAYFLETSKR LANQIPFIIQ YFMLRENGDS
   661  LQKAMMQILQ EKNRYSWLLQ EQSETATKRR ILKERIYRLT QARHALCQFS SKEIH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MX2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
28 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 28 nTPM
  • spleen: 20 nTPM
  • appendix: 16 nTPM
  • urinary bladder: 14 nTPM
  • lymph node: 13 nTPM
  • tonsil: 13 nTPM

Single-cell type

  • neutrophils: 1,075 nCPM
  • urothelial cells: 264 nCPM
  • foveolar cells: 212 nCPM
  • monocytes: 168 nCPM
  • pdcs: 134 nCPM
  • neutrophil progenitors: 71 nCPM

Immune cell

  • neutrophil: 152 nTPM
  • intermediate monocyte: 38 nTPM
  • non-classical monocyte: 36 nTPM
  • classical monocyte: 32 nTPM
  • eosinophil: 25 nTPM
  • myeloid DC: 23 nTPM

Brain region

  • spinal cord: 8.8 nTPM
  • medulla oblongata: 6.8 nTPM
  • pons: 2.9 nTPM
  • white matter: 2.4 nTPM
  • midbrain: 2 nTPM
  • thalamus: 1.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.8
gnomAD pLI
0
gnomAD missense Z
0.58
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MX2 as an antibody target. Whether an autoantibody or antibody against MX2 could matter depends on whether native MX2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MX2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MX2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MX2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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