KIF9

Protein identityUniProt · HPA

UniProt accession

Q9HAQ2

Gene

KIF9

Ensembl

ENSG00000088727

Chromosome

3

Canonical length

790 aa

Protein class

Predicted intracellular proteins

Subcellular location

Primary cilium,Primary cilium tip,Cytosol,Mid piece

OverviewNCBI Gene

Enables identical protein binding activity. Involved in extracellular matrix disassembly; organelle disassembly; and regulation of podosome assembly. Located in microtubule; podosome; and vesicle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

790 residues, UniProt reviewed canonical sequence.

>Q9HAQ2|KIF9
     1  MGTRKKVHAF VRVKPTDDFA HEMIRYGDDK RSIDIHLKKD IRRGVVNNQQ TDWSFKLDGV
    61  LHDASQDLVY ETVAKDVVSQ ALDGYNGTIM CYGQTGAGKT YTMMGATENY KHRGILPRAL
   121  QQVFRMIEER PTHAITVRVS YLEIYNESLF DLLSTLPYVG PSVTPMTIVE NPQGVFIKGL
   181  SVHLTSQEED AFSLLFEGET NRIIASHTMN KNSSRSHCIF TIYLEAHSRT LSEEKYITSK
   241  INLVDLAGSE RLGKSGSEGQ VLKEATYINK SLSFLEQAII ALGDQKRDHI PFRQCKLTHA
   301  LKDSLGGNCN MVLVTNIYGE AAQLEETLSS LRFASRMKLV TTEPAINEKY DAERMVKNLE
   361  KELALLKQEL AIHDSLTNRT FVTYDPMDEI QIAEINSQVR RYLEGTLDEI DIISLRQIKE
   421  VFNQFRVVLS QQEQEVESTL RRKYTLIDRN DFAAISAIQK AGLVDVDGHL VGEPEGQNFG
   481  LGVAPFSTKP GKKAKSKKTF KEPLSSLARK EGASSPVNGK DLDYVSTSKT QLVPSSKDGD
   541  VKDMLSRDRE TSSIEPLPSD SPKEELRPIR PDTPPSKPVA FEEFKNEQGS EINRIFKENK
   601  SILNERRKRA SETTQHINAI KREIDVTKEA LNFQKSLREK QGKYENKGLM IIDEEEFLLI
   661  LKLKDLKKQY RSEYQDLRDL RAEIQYCQHL VDQCRHRLLM EFDIWYNESF VIPEDMQMAL
   721  KPGGSIRPGM VPVNRIVSLG EDDQDKFSQL QQRVLPEGPD SISFYNAKVK IEQKHNYLKT
   781  MMGLQQAHRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIF9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.37

Highest tissue expression

107 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.14

gnomAD pLI

0

gnomAD missense Z

0.58

DepMap mean gene effect

-0.04

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• extracellular matrix disassembly
• microtubule-based movement
• organelle disassembly
• regulation of flagellated sperm motility
• regulation of podosome assembly

Molecular functions

• ATP binding
• ATP hydrolysis activity
• identical protein binding
• microtubule binding
• microtubule motor activity

Cellular components

• cytoplasm
• kinesin complex
• microtubule
• podosome
• sperm flagellum
• vesicle

Protein domainsUniProt · Pfam · InterPro

• Kinesin motor domain
• Kinesin motor domain, conserved site
• P-loop containing nucleoside triphosphate hydrolase
• Kinesin-like protein
• Kinesin motor domain superfamily
• Kinesin-like protein KIF6/9, C-terminal
• Kinesin motor domain
• Kinesin-like protein KIF9 domain

KeywordsUniProt

• ATP-binding
• Cell projection
• Cilium
• Coiled coil
• Cytoplasm
• Cytoskeleton
• Flagellum
• Microtubule
• Motor protein
• Nucleotide-binding
• Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of KIF9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• HYDIN
• PRMT6