Seroatlas · Human Serome Atlas

GNAO1

Guanine nucleotide-binding protein G(o) subunit alpha

Also known as: G-ALPHA-o, GNAO_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P09471
Gene
GNAO1
Ensembl
ENSG00000087258
Chromosome
16
Canonical length
354 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene represents the alpha subunit of the Go heterotrimeric G-protein signal-transducing complex. Defects in this gene are a cause of early-onset epileptic encephalopathy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

Canonical amino-acid sequenceUniProt

354 residues, UniProt reviewed canonical sequence.

>P09471|GNAO1
     1  MGCTLSAEER AALERSKAIE KNLKEDGISA AKDVKLLLLG AGESGKSTIV KQMKIIHEDG
    61  FSGEDVKQYK PVVYSNTIQS LAAIVRAMDT LGIEYGDKER KADAKMVCDV VSRMEDTEPF
   121  SAELLSAMMR LWGDSGIQEC FNRSREYQLN DSAKYYLDSL DRIGAADYQP TEQDILRTRV
   181  KTTGIVETHF TFKNLHFRLF DVGGQRSERK KWIHCFEDVT AIIFCVALSG YDQVLHEDET
   241  TNRMHESLML FDSICNNKFF IDTSIILFLN KKDLFGEKIK KSPLTICFPE YTGPNTYEDA
   301  AAYIQAQFES KNRSPNKEIY CHMTCATDTN NIQVVFDAVT DIIIANNLRG CGLY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GNAO1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
133 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 133 nTPM
  • cerebral cortex: 127 nTPM
  • amygdala: 121 nTPM
  • hippocampal formation: 107 nTPM
  • cerebellum: 91 nTPM
  • hypothalamus: 88 nTPM

Single-cell type

  • oligodendrocytes: 623 nCPM
  • bergmann glia: 458 nCPM
  • retinal bipolar cells: 455 nCPM
  • astrocytes: 298 nCPM
  • thyrotrophs: 265 nCPM
  • brain inhibitory neurons: 255 nCPM

Immune cell

  • gdT-cell: 0.2 nTPM
  • memory CD4 T-cell: 0.1 nTPM
  • naive CD4 T-cell: 0.1 nTPM
  • naive CD8 T-cell: 0.1 nTPM
  • total PBMC: 0.1 nTPM
  • basophil: 0 nTPM

Brain region

  • cerebral cortex: 415 nTPM
  • basal ganglia: 295 nTPM
  • white matter: 278 nTPM
  • thalamus: 272 nTPM
  • amygdala: 261 nTPM
  • hippocampal formation: 244 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GNAO1.

Disease | AllUniProt

Conditions GNAO1 is implicated in, by any mechanism.

  • Developmental and epileptic encephalopathy 17 (DEE17) MIM:615473
  • Neurodevelopmental disorder with involuntary movements (NEDIM) MIM:617493

Disease | GeneticClinVar

100 pathogenic / likely-pathogenic of 583 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.26
gnomAD pLI
0.99
gnomAD missense Z
3.19
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GNAO1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GNAO1 as an antibody target. Whether an autoantibody or antibody against GNAO1 could matter depends on whether native GNAO1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GNAO1 is annotated at the cell surface, where native GNAO1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GNAO1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GNAO1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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