Seroatlas · Human Serome Atlas

SULT1A1

Sulfotransferase 1A1

Also known as: P-PST, ST1A1_HUMAN, STP, STP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P50225
Gene: SULT1A1
Ensembl: ENSG00000196502
Chromosome: 16
Canonical length: 295 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Multiple alternatively spliced variants that encode two isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

295 residues, UniProt reviewed canonical sequence.

>P50225|SULT1A1
     1  MELIQDTSRP PLEYVKGVPL IKYFAEALGP LQSFQARPDD LLISTYPKSG TTWVSQILDM
    61  IYQGGDLEKC HRAPIFMRVP FLEFKAPGIP SGMETLKDTP APRLLKTHLP LALLPQTLLD
   121  QKVKVVYVAR NAKDVAVSYY HFYHMAKVHP EPGTWDSFLE KFMVGEVSYG SWYQHVQEWW
   181  ELSRTHPVLY LFYEDMKENP KREIQKILEF VGRSLPEETV DFVVQHTSFK EMKKNPMTNY
   241  TTVPQEFMDH SISPFMRKGM AGDWKTTFTV AQNERFDADY AEKMAGCSLS FRSEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SULT1A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 191 nTPM

Expression across tissuesHPA

Tissue

liver: 191 nTPM
duodenum: 105 nTPM
small intestine: 85 nTPM
adrenal gland: 73 nTPM
choroid plexus: 67 nTPM
spleen: 49 nTPM

Single-cell type

brain excitatory neurons: 65 nCPM
brain inhibitory neurons: 59 nCPM
podocytes: 52 nCPM
other brain neurons: 50 nCPM
choroid plexus epithelial cells: 47 nCPM
oligodendrocyte progenitor cells: 47 nCPM

Immune cell

classical monocyte: 245 nTPM
neutrophil: 227 nTPM
intermediate monocyte: 201 nTPM
total PBMC: 123 nTPM
non-classical monocyte: 114 nTPM
myeloid DC: 112 nTPM

Brain region

choroid plexus: 29 nTPM
hippocampal formation: 17 nTPM
pons: 14 nTPM
medulla oblongata: 14 nTPM
cerebral cortex: 14 nTPM
basal ganglia: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.54
gnomAD pLI: 0
gnomAD missense Z: -1.19
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SULT1A1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SULT2B1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SULT1A1 as an antibody target. Whether an autoantibody or antibody against SULT1A1 could matter depends on whether native SULT1A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SULT1A1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SULT1A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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