RAB3A
Ras-related protein Rab-3A
Also known as: RAB3A_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P20336
- Gene
- RAB3A
- Ensembl
- ENSG00000105649
- Chromosome
- 19
- Canonical length
- 220 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Centrosome,Cytosol
OverviewNCBI Gene
Enables GTPase activity and myosin V binding activity. Involved in several processes, including acrosomal vesicle exocytosis; plasma membrane repair; and regulation of plasma membrane repair. Located in perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
220 residues, UniProt reviewed canonical sequence.
>P20336|RAB3A
1 MASATDSRYG QKESSDQNFD YMFKILIIGN SSVGKTSFLF RYADDSFTPA FVSTVGIDFK
61 VKTIYRNDKR IKLQIWDTAG QERYRTITTA YYRGAMGFIL MYDITNEESF NAVQDWSTQI
121 KTYSWDNAQV LLVGNKCDME DERVVSSERG RQLADHLGFE FFEASAKDNI NVKQTFERLV
181 DVICEKMSES LDTADPAVTG AKQGPQLSDQ QVPPHQDCACLocalizationUniProt · AlphaFold · HPA
Whether an antibody against RAB3A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.35
- Highest tissue expression
- 340 nTPM
Expression across tissuesHPA
Tissue
- cerebral cortex: 340 nTPM
- cerebellum: 185 nTPM
- hippocampal formation: 179 nTPM
- basal ganglia: 153 nTPM
- hypothalamus: 146 nTPM
- amygdala: 146 nTPM
Single-cell type
- retinal horizontal cells: 64 nCPM
- other brain neurons: 60 nCPM
- retinal amacrine cells: 59 nCPM
- brain inhibitory neurons: 58 nCPM
- retinal bipolar cells: 57 nCPM
- brain excitatory neurons: 51 nCPM
Immune cell
- myeloid DC: 2.9 nTPM
- plasmacytoid DC: 2.6 nTPM
- neutrophil: 2.2 nTPM
- memory B-cell: 1.9 nTPM
- eosinophil: 1.8 nTPM
- MAIT T-cell: 1.8 nTPM
Brain region
- cerebral cortex: 869 nTPM
- white matter: 447 nTPM
- basal ganglia: 330 nTPM
- hippocampal formation: 310 nTPM
- hypothalamus: 300 nTPM
- thalamus: 297 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about RAB3A.
Disease | GeneticClinVar
1 pathogenic / likely-pathogenic of 30 ClinVar records.
Conditions with pathogenic or likely-pathogenic variants.
- RAB3A-related condition
- RAB3A-related disorder
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.32
- gnomAD pLI
- 0.95
- gnomAD missense Z
- 2.32
- DepMap mean gene effect
- -0.15
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- acrosomal vesicle exocytosis
- axonogenesis
- constitutive secretory pathway
- exocytosis
- insulin secretion
- lung development
- lysosome localization
- maintenance of presynaptic active zone structure
- mitochondrion organization
- neuromuscular synaptic transmission
- plasma membrane repair
- positive regulation of exocytosis
- positive regulation of regulated secretory pathway
- post-embryonic development
- regulated exocytosis
- regulation of plasma membrane repair
- regulation of short-term neuronal synaptic plasticity
- regulation of synaptic vesicle fusion to presynaptic active zone membrane
- respiratory system process
- response to electrical stimulus
- sensory perception of touch
- synaptic vesicle clustering
- synaptic vesicle exocytosis
- synaptic vesicle maturation
- synaptic vesicle recycling
- synaptic vesicle transport
- evoked neurotransmitter secretion
- regulation of presynaptic dense core granule exocytosis
Molecular functions
- G protein activity
- GTP binding
- GTP-dependent protein binding
- GTPase activity
- metal ion binding
- myosin V binding
- protein-macromolecule adaptor activity
Cellular components
- acrosomal vesicle
- axon
- clathrin-sculpted acetylcholine transport vesicle membrane
- clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
- clathrin-sculpted glutamate transport vesicle membrane
- clathrin-sculpted monoamine transport vesicle membrane
- cytosol
- endosome
- extracellular vesicle
- lysosome
- perinuclear region of cytoplasm
- plasma membrane
- postsynapse
- presynapse
- presynaptic active zone
- secretory granule membrane
- synaptic vesicle
- synaptic vesicle membrane
- terminal bouton
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of RAB3A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RAB3A as an antibody target. Whether an autoantibody or antibody against RAB3A could matter depends on whether native RAB3A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RAB3A is annotated at the cell surface, where native RAB3A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label RAB3A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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