Seroatlas · Human Serome Atlas

RND3

Rho-related GTP-binding protein RhoE

Also known as: ARHE, Rho8, RhoE, RND3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P61587
Gene
RND3
Ensembl
ENSG00000115963
Chromosome
2
Canonical length
244 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a protein which is a member of the small GTPase protein superfamily. The encoded protein binds only GTP but has no GTPase activity, and appears to act as a negative regulator of cytoskeletal organization leading to loss of adhesion. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]

Canonical amino-acid sequenceUniProt

244 residues, UniProt reviewed canonical sequence.

>P61587|RND3
     1  MKERRASQKL SSKSIMDPNQ NVKCKIVVVG DSQCGKTALL HVFAKDCFPE NYVPTVFENY
    61  TASFEIDTQR IELSLWDTSG SPYYDNVRPL SYPDSDAVLI CFDISRPETL DSVLKKWKGE
   121  IQEFCPNTKM LLVGCKSDLR TDVSTLVELS NHRQTPVSYD QGANMAKQIG AATYIECSAL
   181  QSENSVRDIF HVATLACVNK TNKNVKRNKS QRATKRISHM PSRPELSAVA TDLRKDKAKS
   241  CTVM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RND3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
146 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 146 nTPM
  • liver: 123 nTPM
  • urinary bladder: 101 nTPM
  • breast: 93 nTPM
  • smooth muscle: 58 nTPM
  • gallbladder: 56 nTPM

Single-cell type

  • basal keratinocytes: 1,449 nCPM
  • ocular epithelial cells: 950 nCPM
  • suprabasal keratinocytes: 815 nCPM
  • esophageal apical cells: 796 nCPM
  • endometrial secretory cells: 744 nCPM
  • urothelial cells: 599 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • pons: 34 nTPM
  • hypothalamus: 25 nTPM
  • amygdala: 20 nTPM
  • thalamus: 16 nTPM
  • cerebral cortex: 14 nTPM
  • hippocampal formation: 13 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RND3.

Disease | ImmuneIEDB

Conditions an epitope on RND3 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.28
gnomAD pLI
0.97
gnomAD missense Z
1.65
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RND3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RND3 as an antibody target. Whether an autoantibody or antibody against RND3 could matter depends on whether native RND3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RND3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RND3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RND3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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