Seroatlas · Human Serome Atlas

RAB44

Ras-related protein Rab-44

Also known as: dJ431A14.3, RAB44_HUMAN, RASD3, RASL13

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z6P3
Gene: RAB44
Ensembl: ENSG00000255587
Chromosome: 6
Canonical length: 1021 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in vesicle-mediated transport. Predicted to act upstream of or within histamine secretion by mast cell and histamine secretion mediated by IgE immunoglobulin. Predicted to be located in azurophil granule membrane; plasma membrane; and specific granule membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1021 residues, UniProt reviewed canonical sequence.

>Q7Z6P3|RAB44
     1  METGQRTSRK VRKLGSNRRR QTREPADGEG AAVAPEPESW SSQAAAELQA FFQDCGAKER
    61  GFVTREDLAV AKFSFLGSKE ESEMIFDWVD VERKGHLSLE EFSSGLKNIF GSSQSPHRLR
   121  RRKPLPSKRV SATTSFPALE EADAEEKEAF LAFMEQLGTG HLLPKQMEIW QLWGQLRQEE
   181  PQLAGNLAGF LAKMTSRLQE AQADKEALEL TLRKRDSDHH REVQQLYEEM EQQIRQEKQQ
   241  LQAESDSRGL ALTSQMQDVL EAKEREVQRL AEGQRELEAQ LSHLRSTHQE AASENQQLQE
   301  AKRDLAGRLE EVRGQLQVTR GRLDAARGRV SWQVEEKLSF PGAGEKTPDP QAASPEEAPL
   361  PGLFGDNDDW DQLLSNFGSP PHGALQLCWS PPPTPRATSG PQTPRVVRQI SISEPQAFLF
   421  GQEPSSDPDG APRTPPGVTF SAKDNKGVDP HEQDIRAEQP VEPHDPDPNQ EPGSTPEGRL
   481  LWGLSGSLVA PAFKVLIPLE DGPPPPANSP PPQAPAGSSK QIQASDPDDK GPGSWAPPSG
   541  AQPGAGAGPQ EPTQTPPTMT ERETQPGPSP TTALTGVGPA KPPRQRDALQ QDLHATGSEP
   601  RLGTQRARAL TLGPAEPFQG LEFVGPVPTE RLEQGQAGPA VQEGLPEGLR EAHGQVLGLG
   661  ELSAFPHQEL EEEPRSEEGK QEGRGGQDLS SEQSEQSVEA HGLETAHSEL PQQDSLLVSL
   721  PSATPQAQVE AEGPTPGKSA PPRGSPPRGA QPGAGAGPQE PTQTPPTMAE QEAQPRPSLT
   781  TAHAEEQGPP HSREPRAESR LEDPGMDSRE AGLTPSPGDP MAGGGPQANP DYLFHVIFLG
   841  DSNVGKTSFL HLLHQNSFAT GLTATVGVDF RVKTLLVDNK CFVLQLWDTA GQERYHSMTR
   901  QLLRKADGVV LMYDITSQES FAHVRYWLDC LQDAGSDGVV ILLLGNKMDC EEERQVSVEA
   961  GQQLAQELGV YFGECSAALG HNILEPVVNL ARSLRMQEEG LKDSLVKVAP KRPPKRFGCC
  1021  S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB44 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 56 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 56 nTPM
spleen: 1.3 nTPM
lung: 1.2 nTPM
small intestine: 0.8 nTPM
urinary bladder: 0.8 nTPM
adipose tissue: 0.7 nTPM

Single-cell type

neutrophil progenitors: 88 nCPM
mast cells: 78 nCPM
epicardial cells: 61 nCPM
monocyte progenitors: 54 nCPM
salivary myoepithelial cells: 33 nCPM
endometrial luminal cells: 23 nCPM

Immune cell

basophil: 11 nTPM
eosinophil: 7.2 nTPM
classical monocyte: 0.8 nTPM
myeloid DC: 0.7 nTPM
intermediate monocyte: 0.5 nTPM
total PBMC: 0.2 nTPM

Brain region

basal ganglia: 0.4 nTPM
cerebral cortex: 0.3 nTPM
thalamus: 0.1 nTPM
white matter: 0.1 nTPM
amygdala: 0 nTPM
cerebellum: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.03
gnomAD pLI: 0
gnomAD missense Z: 1.02

OntologyGO

Biological processes

histamine secretion by mast cell
mast cell degranulation
vesicle-mediated transport
histamine secretion mediated by IgE immunoglobulin

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB44 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB44 as an antibody target. Whether an autoantibody or antibody against RAB44 could matter depends on whether native RAB44 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB44 is annotated at the cell surface, where native RAB44 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RAB44 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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