Seroatlas · Human Serome Atlas

HS3ST6

Heparan sulfate glucosamine 3-O-sulfotransferase 6

Also known as: HS3S6_HUMAN, HS3ST5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96QI5
Gene
HS3ST6
Ensembl
ENSG00000162040
Chromosome
16
Canonical length
342 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable [heparan sulfate]-glucosamine 3-sulfotransferase activity. Predicted to be involved in heparan sulfate proteoglycan biosynthetic process. Predicted to act upstream of or within blastocyst hatching. Predicted to be located in Golgi membrane. Implicated in hereditary angioedema. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

342 residues, UniProt reviewed canonical sequence.

>Q96QI5|HS3ST6
     1  MAGSGGLGGG AGGGQGAGAG QGAALRASRA PMLLVALVLG AYCLCALPGR CPPAARAPAP
    61  APAPSEPSSS VHRPGAPGLP LASGPGRRRF PQALIVGVKK GGTRALLEFL RLHPDVRALG
   121  SEPHFFDRCY ERGLAWYRSL MPRTLDGQIT MEKTPSYFVT REAPRRIHAM SPDTKLIVVV
   181  RNPVTRAISD YAQTLSKTPG LPSFRALAFR HGLGPVDTAW SAVRIGLYAQ HLDHWLRYFP
   241  LSHFLFVSGE RLVSDPAGEV GRVQDFLGLK RVVTDKHFYF NATKGFPCLK KAQGGSRPRC
   301  LGKSKGRPHP RVPQALVRRL QEFYRPFNRR FYQMTGQDFG WG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HS3ST6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
75 nTPM

Expression across tissuesHPA

Tissue

  • skin: 75 nTPM
  • esophagus: 14 nTPM
  • cervix: 10 nTPM
  • vagina: 10 nTPM
  • urinary bladder: 3.5 nTPM
  • salivary gland: 1.8 nTPM

Single-cell type

  • papillary tip epithelial cells: 10 nCPM
  • proximal tubule cells: 1.8 nCPM
  • loop of henle epithelial cells: 1 nCPM
  • renal collecting duct principal cells: 0.7 nCPM
  • prostatic hillock cells: 0.4 nCPM
  • salivary ionocytes: 0.4 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 0.1 nTPM
  • pons: 0.1 nTPM
  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • choroid plexus: 0 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HS3ST6.

Disease | AllUniProt

Conditions HS3ST6 is implicated in, by any mechanism.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 83 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Angioedema, hereditary, 8

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.88
gnomAD pLI
0.44
gnomAD missense Z
-0.04
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HS3ST6 as an antibody target. Whether an autoantibody or antibody against HS3ST6 could matter depends on whether native HS3ST6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HS3ST6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HS3ST6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HS3ST6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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